ABAT Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ABAT-specific vectors and viral particles designed for reliable ABAT overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ABAT CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ABAT Gene Overview
| Gene Name | 4-aminobutyrate aminotransferase |
|---|---|
| Gene Symbol | ABAT |
| Synonyms | GABAT,NPD009,GABA-AT |
| NCBI ID | 18 |
| Ensembl ID | ENSG00000183044 |
| Uniprot ID | P80404 |
| Gene Type | Protein coding |
Gene Summary
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Human ABAT Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC111007 | View Product |
| Stable overexpression | LC311007 | View Product | |
| AAV Vector & Virus | Long-term expression | VC111007 | View Product |
| Adenovirus | Transient expression | A111007 | View Product |
| Transient expression | A311007 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG111007 | View Product |
| Gene knockout (non-viral) | PG111007 | View Product | |
| Gene knockout (AAV) | VG111007 | View Product | |
| CRISPR Activation | Gene activation | LA111007 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS111007 | View Product |
| Gene knockdown (AAV) | VS111007 | View Product | |
| ORF Vector | Template DNA | PC111007 | View Product |
| Template DNA | PC311007 | View Product |
Mouse Abat Gene Overview
| Gene Name | 4-aminobutyrate aminotransferase |
|---|---|
| Gene Symbol | Abat |
| Synonyms | I54,Gabat,Gabaat,Gm9851,Laibat,9630038C02Rik |
| NCBI ID | 268860 |
| Ensembl ID | ENSMUSG00000057880 |
| Uniprot ID | P61922 |
| Gene Type | Protein coding |
Gene Summary
The encoded gene product is responsible for catabolism of gamma-aminobutyric acid (GABA), a mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. Deficiency of this encoded protein includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Mouse Abat Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC411007 | View Product |
| Stable overexpression | LC511007 | View Product | |
| AAV Vector & Virus | Long-term expression | VC411007 | View Product |
| Long-term expression | VC511007 | View Product | |
| Adenovirus | Transient expression | A411007 | View Product |
| Transient expression | A511007 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG411007 | View Product |
| Gene knockout (non-viral) | PG411007 | View Product | |
| Gene knockout (AAV) | VG411007 | View Product | |
| CRISPR Activation | Gene activation | LA411007 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS411007 | View Product |
| Gene knockdown (AAV) | VS411007 | View Product | |
| ORF Vector | Template DNA | PC411007 | View Product |
| Template DNA | PC511007 | View Product |
Rat Abat Gene Overview
| Gene Name | 4-aminobutyrate aminotransferase |
|---|---|
| Gene Symbol | Abat |
| Synonyms | Gabat,beta-AlaAT |
| NCBI ID | 81632 |
| Ensembl ID | ENSRNOG00000002636 |
| Uniprot ID | P50554 |
| Gene Type | Protein coding |
Gene Summary
Enables 4-aminobutyrate:2-oxoglutarate transaminase activity. Involved in several processes, including gamma-aminobutyric acid biosynthetic process; positive regulation of inhibitory postsynaptic potential; and regulation of secretion. Located in mitochondrial matrix. Used to study several diseases, including Huntington's disease; depressive disorder; epilepsy (multiple); heroin dependence; and ischemia. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Jul 2025]
Rat Abat Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC611007 | View Product |
| AAV Vector & Virus | Long-term expression | VC611007 | View Product |
| Adenovirus | Transient expression | A611007 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG611007 | View Product |
| Gene knockout (non-viral) | PG611007 | View Product | |
| Gene knockout (AAV) | VG611007 | View Product | |
| CRISPR Activation | Gene activation | LA611007 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS611007 | View Product |
| Gene knockdown (AAV) | VS611007 | View Product | |
| ORF Vector | Template DNA | PC611007 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |