ACE2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ACE2-specific vectors and viral particles designed for reliable ACE2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ACE2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ACE2 Gene Overview
| Gene Name | angiotensin converting enzyme 2 |
|---|---|
| Gene Symbol | ACE2 |
| Synonyms | ACEH |
| NCBI ID | 59272 |
| Ensembl ID | ENSG00000130234 |
| Uniprot ID | Q9BYF1 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020]
Human ACE2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC111167 | View Product |
| AAV Vector & Virus | Long-term expression | VC111167 | View Product |
| Adenovirus | Transient expression | A111167 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG111167 | View Product |
| Gene knockout (non-viral) | PG111167 | View Product | |
| Gene knockout (AAV) | VG111167 | View Product | |
| CRISPR Activation | Gene activation | LA111167 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS111167 | View Product |
| Gene knockdown (AAV) | VS111167 | View Product | |
| ORF Vector | Template DNA | PC111167 | View Product |
Mouse Ace2 Gene Overview
| Gene Name | angiotensin converting enzyme 2 |
|---|---|
| Gene Symbol | Ace2 |
| Synonyms | 2010305L05Rik |
| NCBI ID | 70008 |
| Ensembl ID | ENSMUSG00000015405 |
| Uniprot ID | Q8R0I0 |
| Gene Type | Protein coding |
Gene Summary
Enables metallocarboxypeptidase activity. Involved in angiotensin maturation; positive regulation of cardiac muscle contraction; and tryptophan transport. Located in brush border membrane and cytoplasm. Is active in extracellular region. Is expressed in several structures, including blastocyst; brain; early embryo; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ace2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC411167 | View Product |
| Stable overexpression | LC511167 | View Product | |
| AAV Vector & Virus | Long-term expression | VC411167 | View Product |
| Long-term expression | VC511167 | View Product | |
| Adenovirus | Transient expression | A411167 | View Product |
| Transient expression | A511167 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG411167 | View Product |
| Gene knockout (non-viral) | PG411167 | View Product | |
| Gene knockout (AAV) | VG411167 | View Product | |
| CRISPR Activation | Gene activation | LA411167 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS411167 | View Product |
| Gene knockdown (AAV) | VS411167 | View Product | |
| ORF Vector | Template DNA | PC411167 | View Product |
| Template DNA | PC511167 | View Product |
Rat Ace2 Gene Overview
| Gene Name | angiotensin converting enzyme 2 |
|---|---|
| Gene Symbol | Ace2 |
| Synonyms | |
| NCBI ID | 302668 |
| Ensembl ID | ENSRNOG00000031665 |
| Uniprot ID | Q5EGZ1 |
| Gene Type | Protein coding |
Gene Summary
Enables carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Located in extracellular space. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ace2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC611167 | View Product |
| AAV Vector & Virus | Long-term expression | VC611167 | View Product |
| Adenovirus | Transient expression | A611167 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG611167 | View Product |
| Gene knockout (non-viral) | PG611167 | View Product | |
| Gene knockout (AAV) | VG611167 | View Product | |
| CRISPR Activation | Gene activation | LA611167 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS611167 | View Product |
| Gene knockdown (AAV) | VS611167 | View Product | |
| ORF Vector | Template DNA | PC611167 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |