AGER Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use AGER-specific vectors and viral particles designed for reliable AGER overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including AGER CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human AGER Gene Overview
| Gene Name | advanced glycosylation end-product specific receptor |
|---|---|
| Gene Symbol | AGER |
| Synonyms | RAGE,sRAGE,SCARJ1 |
| NCBI ID | 177 |
| Ensembl ID | ENSG00000204305 |
| Uniprot ID | Q15109 |
| Gene Type | Protein coding |
Gene Summary
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
Human AGER Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC111512 | View Product |
| AAV Vector & Virus | Long-term expression | VC111512 | View Product |
| Adenovirus | Transient expression | A111512 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG111512 | View Product |
| Gene knockout (non-viral) | PG111512 | View Product | |
| Gene knockout (AAV) | VG111512 | View Product | |
| CRISPR Activation | Gene activation | LA111512 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS111512 | View Product |
| Gene knockdown (AAV) | VS111512 | View Product | |
| ORF Vector | Template DNA | PC111512 | View Product |
Mouse Ager Gene Overview
| Gene Name | advanced glycosylation end product-specific receptor |
|---|---|
| Gene Symbol | Ager |
| Synonyms | RAGE |
| NCBI ID | 11596 |
| Ensembl ID | ENSMUSG00000015452 |
| Uniprot ID | Q62151 |
| Gene Type | Protein coding |
Gene Summary
Enables S100 protein binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including astrocyte development; induction of positive chemotaxis; and positive regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ager Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC411512 | View Product |
| AAV Vector & Virus | Long-term expression | VC411512 | View Product |
| Long-term expression | VC511512 | View Product | |
| Adenovirus | Transient expression | A411512 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG411512 | View Product |
| Gene knockout (non-viral) | PG411512 | View Product | |
| Gene knockout (AAV) | VG411512 | View Product | |
| CRISPR Activation | Gene activation | LA411512 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS411512 | View Product |
| Gene knockdown (AAV) | VS411512 | View Product | |
| ORF Vector | Template DNA | PC411512 | View Product |
Rat Ager Gene Overview
| Gene Name | advanced glycosylation end product-specific receptor |
|---|---|
| Gene Symbol | Ager |
| Synonyms | RAGE |
| NCBI ID | 81722 |
| Ensembl ID | ENSRNOG00000000439 |
| Uniprot ID | Q63495 |
| Gene Type | Protein coding |
Gene Summary
Enables S100 protein binding activity and high mobility group box 1 binding activity. Involved in several processes, including positive regulation of apoptotic process; positive regulation of metabolic process; and regulation of cell migration. Located in several cellular components, including basal plasma membrane; cell surface; and neuronal cell body. Used to study several diseases, including diabetic retinopathy; impotence; renal fibrosis; thromboangiitis obliterans; and type 2 diabetes mellitus. Biomarker of several diseases, including alcohol use disorder; bone disease (multiple); cardiovascular system disease (multiple); gastrointestinal system disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ager Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC611512 | View Product |
| AAV Vector & Virus | Long-term expression | VC611512 | View Product |
| Adenovirus | Transient expression | A611512 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG611512 | View Product |
| Gene knockout (non-viral) | PG611512 | View Product | |
| Gene knockout (AAV) | VG611512 | View Product | |
| CRISPR Activation | Gene activation | LA611512 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS611512 | View Product |
| Gene knockdown (AAV) | VS611512 | View Product | |
| ORF Vector | Template DNA | PC611512 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |