ALDH2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ALDH2-specific vectors and viral particles designed for reliable ALDH2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ALDH2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ALDH2 Gene Overview
| Gene Name | aldehyde dehydrogenase 2 family member |
|---|---|
| Gene Symbol | ALDH2 |
| Synonyms | ALDM,ALDHI,ALDH-E2 |
| NCBI ID | 217 |
| Ensembl ID | ENSG00000111275 |
| Uniprot ID | P05091 |
| Gene Type | Protein coding |
Gene Summary
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]
Human ALDH2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC111732 | View Product |
| AAV Vector & Virus | Long-term expression | VC111732 | View Product |
| Adenovirus | Transient expression | A111732 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG111732 | View Product |
| Gene knockout (non-viral) | PG111732 | View Product | |
| Gene knockout (AAV) | VG111732 | View Product | |
| CRISPR Activation | Gene activation | LA111732 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS111732 | View Product |
| Gene knockdown (AAV) | VS111732 | View Product | |
| ORF Vector | Template DNA | PC111732 | View Product |
Mouse Aldh2 Gene Overview
| Gene Name | aldehyde dehydrogenase 2, mitochondrial |
|---|---|
| Gene Symbol | Aldh2 |
| Synonyms | Ahd5,ALDHI,Ahd-5,AHD-M1,ALDH-E2 |
| NCBI ID | 11669 |
| Ensembl ID | ENSMUSG00000029455 |
| Uniprot ID | P47738 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including NADH binding activity; carboxylesterase activity; and phenylacetaldehyde dehydrogenase (NAD+) activity. Involved in regulation of dopamine biosynthetic process and regulation of serotonin biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Aldh2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC411732 | View Product |
| AAV Vector & Virus | Long-term expression | VC411732 | View Product |
| Adenovirus | Transient expression | A411732 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG411732 | View Product |
| Gene knockout (non-viral) | PG411732 | View Product | |
| Gene knockout (AAV) | VG411732 | View Product | |
| CRISPR Activation | Gene activation | LA411732 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS411732 | View Product |
| Gene knockdown (AAV) | VS411732 | View Product | |
| ORF Vector | Template DNA | PC411732 | View Product |
Rat Aldh2 Gene Overview
| Gene Name | aldehyde dehydrogenase 2 family member |
|---|---|
| Gene Symbol | Aldh2 |
| Synonyms | |
| NCBI ID | 29539 |
| Ensembl ID | ENSRNOG00000073701 |
| Uniprot ID | P11884 |
| Gene Type | Protein coding |
Gene Summary
Enables NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to resveratrol; and response to ischemia. Located in mitochondrial matrix. Used to study metabolic dysfunction and alcohol associated liver disease. Biomarker of heart disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Jul 2025]
Rat Aldh2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC611732 | View Product |
| AAV Vector & Virus | Long-term expression | VC611732 | View Product |
| Adenovirus | Transient expression | A611732 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG611732 | View Product |
| Gene knockout (non-viral) | PG611732 | View Product | |
| Gene knockout (AAV) | VG611732 | View Product | |
| CRISPR Activation | Gene activation | LA611732 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS611732 | View Product |
| Gene knockdown (AAV) | VS611732 | View Product | |
| ORF Vector | Template DNA | PC611732 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |