APP Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use APP-specific vectors and viral particles designed for reliable APP overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including APP CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human APP Gene Overview
| Gene Name | amyloid beta precursor protein |
|---|---|
| Gene Symbol | APP |
| Synonyms | AAA,AD1,PN2,ABPP,APPI,CVAP,ABETA,PN-II,preA4,CTFgamma,alpha-sAPP |
| NCBI ID | 351 |
| Ensembl ID | ENSG00000142192 |
| Uniprot ID | P05067 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Human APP Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC112208 | View Product |
| AAV Vector & Virus | Long-term expression | VC112208 | View Product |
| Adenovirus | Transient expression | A112208 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG112208 | View Product |
| Gene knockout (non-viral) | PG112208 | View Product | |
| Gene knockout (AAV) | VG112208 | View Product | |
| CRISPR Activation | Gene activation | LA112208 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS112208 | View Product |
| Gene knockdown (AAV) | VS112208 | View Product | |
| ORF Vector | Template DNA | PC112208 | View Product |
Mouse App Gene Overview
| Gene Name | amyloid beta precursor protein |
|---|---|
| Gene Symbol | App |
| Synonyms | Ag,Abpp,Adap,Cvap,Abeta,betaApp,E030013M08Rik |
| NCBI ID | 11820 |
| Ensembl ID | ENSMUSG00000022892 |
| Uniprot ID | P12023 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and protein kinase binding activity. Involved in negative regulation of blood circulation; positive regulation of endothelin production; and positive regulation of tumor necrosis factor production. Acts upstream of or within several processes, including intracellular monoatomic cation homeostasis; nervous system development; and regulation of primary metabolic process. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Is active in cell surface; intracellular vesicle; and presynaptic active zone. Is expressed in several structures, including alimentary system; central nervous system; metanephros; peripheral nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and traumatic brain injury. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Jul 2025]
Mouse App Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC412208 | View Product |
| Stable overexpression | LC512208 | View Product | |
| AAV Vector & Virus | Long-term expression | VC412208 | View Product |
| Long-term expression | VC512208 | View Product | |
| Adenovirus | Transient expression | A412208 | View Product |
| Transient expression | A512208 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG412208 | View Product |
| Gene knockout (non-viral) | PG412208 | View Product | |
| Gene knockout (AAV) | VG412208 | View Product | |
| CRISPR Activation | Gene activation | LA412208 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS412208 | View Product |
| Gene knockdown (AAV) | VS412208 | View Product | |
| ORF Vector | Template DNA | PC412208 | View Product |
| Template DNA | PC512208 | View Product |
Rat App Gene Overview
| Gene Name | amyloid beta precursor protein |
|---|---|
| Gene Symbol | App |
| Synonyms | Abeta |
| NCBI ID | 54226 |
| Ensembl ID | ENSRNOG00000006997 |
| Uniprot ID | P08592 |
| Gene Type | Protein coding |
Gene Summary
Enables growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to cAMP; cellular response to norepinephrine stimulus; and defense response to other organism. Located in several cellular components, including astrocyte projection; axon; and cell surface. Is active in neuronal dense core vesicle. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and traumatic brain injury. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2025]
Rat App Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC612208 | View Product |
| AAV Vector & Virus | Long-term expression | VC612208 | View Product |
| Adenovirus | Transient expression | A612208 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG612208 | View Product |
| Gene knockout (non-viral) | PG612208 | View Product | |
| Gene knockout (AAV) | VG612208 | View Product | |
| CRISPR Activation | Gene activation | LA612208 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS612208 | View Product |
| Gene knockdown (AAV) | VS612208 | View Product | |
| ORF Vector | Template DNA | PC612208 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |