AR Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use AR-specific vectors and viral particles designed for reliable AR overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including AR CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human AR Gene Overview
| Gene Name | androgen receptor |
|---|---|
| Gene Symbol | AR |
| Synonyms | KD,AIS,AR8,TFM,DHTR,SBMA,HYSP1,NR3C4,SMAX1,HUMARA |
| NCBI ID | 367 |
| Ensembl ID | ENSG00000169083 |
| Uniprot ID | P10275 |
| Gene Type | Protein coding |
Gene Summary
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Human AR Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| AAV Vector & Virus | Long-term expression | VC112233 | View Product |
| Adenovirus | Transient expression | A112233 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG112233 | View Product |
| Gene knockout (non-viral) | PG112233 | View Product | |
| Gene knockout (AAV) | VG112233 | View Product | |
| CRISPR Activation | Gene activation | LA112233 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS112233 | View Product |
| Gene knockdown (AAV) | VS112233 | View Product | |
| ORF Vector | Template DNA | PC112233 | View Product |
Mouse Ar Gene Overview
| Gene Name | androgen receptor |
|---|---|
| Gene Symbol | Ar |
| Synonyms | Tfm |
| NCBI ID | 11835 |
| Ensembl ID | ENSMUSG00000046532 |
| Uniprot ID | P19091 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male animals. Loss of function in female animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]
Mouse Ar Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC412233 | View Product |
| AAV Vector & Virus | Long-term expression | VC412233 | View Product |
| Adenovirus | Transient expression | A412233 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG412233 | View Product |
| Gene knockout (non-viral) | PG412233 | View Product | |
| Gene knockout (AAV) | VG412233 | View Product | |
| CRISPR Activation | Gene activation | LA412233 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS412233 | View Product |
| Gene knockdown (AAV) | VS412233 | View Product | |
| ORF Vector | Template DNA | PC412233 | View Product |
Rat Ar Gene Overview
| Gene Name | androgen receptor |
|---|---|
| Gene Symbol | Ar |
| Synonyms | Tfm,Andr |
| NCBI ID | 24208 |
| Ensembl ID | ENSRNOG00000005639 |
| Uniprot ID | P15207 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including androgen binding activity; nuclear androgen receptor binding activity; and nuclear receptor activity. Involved in several processes, including androgen receptor signaling pathway; cellular response to follicle-stimulating hormone stimulus; and regulation of DNA-templated transcription. Located in several cellular components, including axon; dendrite; and nuclear matrix. Used to study hypertension; osteoporosis; prostate adenocarcinoma; prostate cancer; and prostatic hypertrophy. Biomarker of acute kidney failure; androgen insensitivity syndrome; and metabolic dysfunction and alcohol associated liver disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; disorder of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Orthologous to human AR (androgen receptor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ar Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC612233 | View Product |
| AAV Vector & Virus | Long-term expression | VC612233 | View Product |
| Adenovirus | Transient expression | A612233 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG612233 | View Product |
| Gene knockout (non-viral) | PG612233 | View Product | |
| Gene knockout (AAV) | VG612233 | View Product | |
| CRISPR Activation | Gene activation | LA612233 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS612233 | View Product |
| Gene knockdown (AAV) | VS612233 | View Product | |
| ORF Vector | Template DNA | PC612233 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |