ASCL1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ASCL1-specific vectors and viral particles designed for reliable ASCL1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ASCL1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ASCL1 Gene Overview
| Gene Name | achaete-scute family bHLH transcription factor 1 |
|---|---|
| Gene Symbol | ASCL1 |
| Synonyms | ASH1,HASH1,MASH1,bHLHa46 |
| NCBI ID | 429 |
| Ensembl ID | ENSG00000139352 |
| Uniprot ID | P50553 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]
Human ASCL1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC112525 | View Product |
| AAV Vector & Virus | Long-term expression | VC112525 | View Product |
| Adenovirus | Transient expression | A112525 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG112525 | View Product |
| Gene knockout (non-viral) | PG112525 | View Product | |
| Gene knockout (AAV) | VG112525 | View Product | |
| CRISPR Activation | Gene activation | LA112525 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS112525 | View Product |
| Gene knockdown (AAV) | VS112525 | View Product | |
| ORF Vector | Template DNA | PC112525 | View Product |
Mouse Ascl1 Gene Overview
| Gene Name | achaete-scute family bHLH transcription factor 1 |
|---|---|
| Gene Symbol | Ascl1 |
| Synonyms | ASH1,Mash1,bHLHa46 |
| NCBI ID | 17172 |
| Ensembl ID | ENSMUSG00000020052 |
| Uniprot ID | Q02067 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in nervous system development and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including brain development; musculoskeletal movement, spinal reflex action; and neurogenesis. Located in neuronal cell body and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ascl1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC412525 | View Product |
| AAV Vector & Virus | Long-term expression | VC412525 | View Product |
| Adenovirus | Transient expression | A412525 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG412525 | View Product |
| Gene knockout (non-viral) | PG412525 | View Product | |
| Gene knockout (AAV) | VG412525 | View Product | |
| CRISPR Activation | Gene activation | LA412525 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS412525 | View Product |
| Gene knockdown (AAV) | VS412525 | View Product | |
| ORF Vector | Template DNA | PC412525 | View Product |
Rat Ascl1 Gene Overview
| Gene Name | achaete-scute family bHLH transcription factor 1 |
|---|---|
| Gene Symbol | Ascl1 |
| Synonyms | Mash1 |
| NCBI ID | 64186 |
| Ensembl ID | ENSRNOG00000085519 |
| Uniprot ID | P19359 |
| Gene Type | Protein coding |
Gene Summary
Enables double-stranded DNA binding activity and identical protein binding activity. Involved in several processes, including cellular response to magnetism; regulation of neuron differentiation; and response to retinoic acid. Predicted to be located in neuronal cell body and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Biomarker of status epilepticus. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ascl1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC612525 | View Product |
| AAV Vector & Virus | Long-term expression | VC612525 | View Product |
| Adenovirus | Transient expression | A612525 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG612525 | View Product |
| Gene knockout (non-viral) | PG612525 | View Product | |
| Gene knockout (AAV) | VG612525 | View Product | |
| CRISPR Activation | Gene activation | LA612525 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS612525 | View Product |
| Gene knockdown (AAV) | VS612525 | View Product | |
| ORF Vector | Template DNA | PC612525 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |