ATF4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ATF4-specific vectors and viral particles designed for reliable ATF4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ATF4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ATF4 Gene Overview
| Gene Name | activating transcription factor 4 |
|---|---|
| Gene Symbol | ATF4 |
| Synonyms | CREB2,TXREB,CREB-2,TAXREB67 |
| NCBI ID | 468 |
| Ensembl ID | ENSG00000128272 |
| Uniprot ID | P18848 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
Human ATF4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC112610 | View Product |
| AAV Vector & Virus | Long-term expression | VC112610 | View Product |
| Adenovirus | Transient expression | A112610 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG112610 | View Product |
| Gene knockout (non-viral) | PG112610 | View Product | |
| Gene knockout (AAV) | VG112610 | View Product | |
| CRISPR Activation | Gene activation | LA112610 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS112610 | View Product |
| Gene knockdown (AAV) | VS112610 | View Product | |
| ORF Vector | Template DNA | PC112610 | View Product |
Mouse Atf4 Gene Overview
| Gene Name | activating transcription factor 4 |
|---|---|
| Gene Symbol | Atf4 |
| Synonyms | Atf-4,C/ATF,CREB2,CREB-2,TAXREB67 |
| NCBI ID | 11911 |
| Ensembl ID | ENSMUSG00000042406 |
| Uniprot ID | Q06507 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and promoter-specific chromatin binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including cellular response to leucine starvation; intracellular signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including gluconeogenesis; positive regulation of sodium-dependent phosphate transport; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of ATF1-ATF4 transcription factor complex and ATF4-CREB1 transcription factor complex. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and long bone. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Atf4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC412610 | View Product |
| AAV Vector & Virus | Long-term expression | VC412610 | View Product |
| Adenovirus | Transient expression | A412610 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG412610 | View Product |
| Gene knockout (non-viral) | PG412610 | View Product | |
| Gene knockout (AAV) | VG412610 | View Product | |
| CRISPR Activation | Gene activation | LA412610 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS412610 | View Product |
| Gene knockdown (AAV) | VS412610 | View Product | |
| ORF Vector | Template DNA | PC412610 | View Product |
Rat Atf4 Gene Overview
| Gene Name | activating transcription factor 4 |
|---|---|
| Gene Symbol | Atf4 |
| Synonyms | |
| NCBI ID | 79255 |
| Ensembl ID | ENSRNOG00000017801 |
| Uniprot ID | Q9ES19 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor binding activity and general transcription initiation factor binding activity. Involved in several processes, including gamma-aminobutyric acid signaling pathway; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; and response to manganese-induced endoplasmic reticulum stress. Located in dendrite membrane. Biomarker of borna disease and pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Rat Atf4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC612610 | View Product |
| AAV Vector & Virus | Long-term expression | VC612610 | View Product |
| Adenovirus | Transient expression | A612610 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG612610 | View Product |
| Gene knockout (non-viral) | PG612610 | View Product | |
| Gene knockout (AAV) | VG612610 | View Product | |
| CRISPR Activation | Gene activation | LA612610 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS612610 | View Product |
| Gene knockdown (AAV) | VS612610 | View Product | |
| ORF Vector | Template DNA | PC612610 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |