ATF6 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ATF6-specific vectors and viral particles designed for reliable ATF6 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ATF6 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ATF6 Gene Overview
| Gene Name | activating transcription factor 6 |
|---|---|
| Gene Symbol | ATF6 |
| Synonyms | ACHM7,ATF6A,ATP6alpha |
| NCBI ID | 22926 |
| Ensembl ID | ENSG00000118217 |
| Uniprot ID | P18850 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Human ATF6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC112616 | View Product |
| AAV Vector & Virus | Long-term expression | VC112616 | View Product |
| Adenovirus | Transient expression | A112616 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG112616 | View Product |
| Gene knockout (non-viral) | PG112616 | View Product | |
| Gene knockout (AAV) | VG112616 | View Product | |
| CRISPR Activation | Gene activation | LA112616 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS112616 | View Product |
| Gene knockdown (AAV) | VS112616 | View Product | |
| ORF Vector | Template DNA | PC112616 | View Product |
Mouse Atf6 Gene Overview
| Gene Name | activating transcription factor 6 |
|---|---|
| Gene Symbol | Atf6 |
| Synonyms | ESTM49,Atf6alpha,9630036G24,9130025P16Rik |
| NCBI ID | 226641 |
| Ensembl ID | ENSMUSG00000026663 |
| Uniprot ID | F6VAN0 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and protein heterodimerization activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; eye; liver; long bone; and tooth. Used to study achromatopsia 7. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Atf6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC412616 | View Product |
| AAV Vector & Virus | Long-term expression | VC412616 | View Product |
| Adenovirus | Transient expression | A412616 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG412616 | View Product |
| Gene knockout (non-viral) | PG412616 | View Product | |
| Gene knockout (AAV) | VG412616 | View Product | |
| CRISPR Activation | Gene activation | LA412616 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS412616 | View Product |
| Gene knockdown (AAV) | VS412616 | View Product | |
| ORF Vector | Template DNA | PC412616 | View Product |
Rat Atf6 Gene Overview
| Gene Name | activating transcription factor 6 |
|---|---|
| Gene Symbol | Atf6 |
| Synonyms | |
| NCBI ID | 304962 |
| Ensembl ID | ENSRNOG00000024632 |
| Uniprot ID | G3V909 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including endoplasmic reticulum unfolded protein response; positive regulation of ATF6-mediated unfolded protein response; and visual perception. Predicted to act upstream of or within positive regulation of autophagy and positive regulation of transcription by RNA polymerase II. Located in nucleus. Biomarker of borna disease. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2025]
Rat Atf6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC612616 | View Product |
| AAV Vector & Virus | Long-term expression | VC612616 | View Product |
| Adenovirus | Transient expression | A612616 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG612616 | View Product |
| Gene knockout (non-viral) | PG612616 | View Product | |
| Gene knockout (AAV) | VG612616 | View Product | |
| CRISPR Activation | Gene activation | LA612616 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS612616 | View Product |
| Gene knockdown (AAV) | VS612616 | View Product | |
| ORF Vector | Template DNA | PC612616 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |