ATM Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ATM-specific vectors and viral particles designed for reliable ATM overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ATM CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ATM Gene Overview
| Gene Name | ATM serine/threonine kinase |
|---|---|
| Gene Symbol | ATM |
| Synonyms | AT1,ATA,ATC,ATD,ATE,ATDC,TEL1,TELO1 |
| NCBI ID | 472 |
| Ensembl ID | ENSG00000149311 |
| Uniprot ID | Q13315 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Human ATM Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC112649 | View Product |
| AAV Vector & Virus | Long-term expression | VC112649 | View Product |
| Adenovirus | Transient expression | A212649 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG112649 | View Product |
| Gene knockout (non-viral) | PG112649 | View Product | |
| Gene knockout (AAV) | VG112649 | View Product | |
| CRISPR Activation | Gene activation | LA112649 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS112649 | View Product |
| Gene knockdown (AAV) | VS112649 | View Product | |
| ORF Vector | Template DNA | PC112649 | View Product |
Mouse Atm Gene Overview
| Gene Name | ataxia telangiectasia mutated |
|---|---|
| Gene Symbol | Atm |
| Synonyms | C030026E19Rik |
| NCBI ID | 11920 |
| Ensembl ID | ENSMUSG00000034218 |
| Uniprot ID | Q62388 |
| Gene Type | Protein coding |
Gene Summary
Enables histone H2AXS139 kinase activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of TORC1 signaling; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including immune system development; intracellular signal transduction; and meiotic nuclear division. Located in cytoplasm; microtubule cytoskeleton; and nucleus. Is extrinsic component of synaptic vesicle membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study ataxia telangiectasia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Atm Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG412649 | View Product |
| Gene knockout (non-viral) | PG412649 | View Product | |
| Gene knockout (AAV) | VG412649 | View Product | |
| CRISPR Activation | Gene activation | LA412649 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS412649 | View Product |
| Gene knockdown (AAV) | VS412649 | View Product |
Rat Atm Gene Overview
| Gene Name | ATM serine/threonine kinase |
|---|---|
| Gene Symbol | Atm |
| Synonyms | |
| NCBI ID | 300711 |
| Ensembl ID | ENSRNOG00000029773 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable identical protein binding activity and phosphotransferase activity, alcohol group as acceptor. Involved in several processes, including cellular response to ionizing radiation; positive regulation of DNA catabolic process; and regulation of microglial cell activation. Predicted to be located in chromosome, telomeric region; microtubule cytoskeleton; and nuclear lumen. Predicted to be part of DNA repair complex. Predicted to be active in nucleus; peroxisomal matrix; and site of double-strand break. Predicted to be extrinsic component of synaptic vesicle membrane. Used to study ataxia telangiectasia; disease of cellular proliferation; infertility; leukemia; and lymphoma. Biomarker of pre-malignant neoplasm and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Rat Atm Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG612649 | View Product |
| Gene knockout (non-viral) | PG612649 | View Product | |
| Gene knockout (AAV) | VG612649 | View Product | |
| CRISPR Activation | Gene activation | LA612649 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS612649 | View Product |
| Gene knockdown (AAV) | VS612649 | View Product | |
| ORF Vector | Template DNA | PC612649 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |