ATP2A2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ATP2A2-specific vectors and viral particles designed for reliable ATP2A2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ATP2A2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ATP2A2 Gene Overview
| Gene Name | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
|---|---|
| Gene Symbol | ATP2A2 |
| Synonyms | DD,DAR,ATP2B,SERCA2,RHABDO2 |
| NCBI ID | 488 |
| Ensembl ID | ENSG00000174437 |
| Uniprot ID | P16615 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]
Human ATP2A2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC112684 | View Product |
| AAV Vector & Virus | Long-term expression | VC112684 | View Product |
| Adenovirus | Transient expression | A112684 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG112684 | View Product |
| Gene knockout (non-viral) | PG112684 | View Product | |
| Gene knockout (AAV) | VG112684 | View Product | |
| CRISPR Activation | Gene activation | LA112684 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS112684 | View Product |
| Gene knockdown (AAV) | VS112684 | View Product | |
| ORF Vector | Template DNA | PC112684 | View Product |
Mouse Atp2a2 Gene Overview
| Gene Name | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
|---|---|
| Gene Symbol | Atp2a2 |
| Synonyms | SERCA2,SERCA2B,Serca2a,D5Wsu150e,mKIAA4195,9530097L16Rik |
| NCBI ID | 11938 |
| Ensembl ID | ENSMUSG00000029467 |
| Uniprot ID | O55143 |
| Gene Type | Protein coding |
Gene Summary
Enables P-type calcium transporter activity; enzyme binding activity; and lncRNA binding activity. Involved in calcium ion import into sarcoplasmic reticulum and calcium ion transmembrane transport. Acts upstream of or within several processes, including T-tubule organization; cardiac muscle hypertrophy in response to stress; and regulation of heart contraction. Located in membrane; ribbon synapse; and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Used to study keratosis follicularis. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Atp2a2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC412684 | View Product |
| Stable overexpression | LC512684 | View Product | |
| AAV Vector & Virus | Long-term expression | VC412684 | View Product |
| Long-term expression | VC512684 | View Product | |
| Adenovirus | Transient expression | A412684 | View Product |
| Transient expression | A512684 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG412684 | View Product |
| Gene knockout (non-viral) | PG412684 | View Product | |
| Gene knockout (AAV) | VG412684 | View Product | |
| CRISPR Activation | Gene activation | LA412684 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS412684 | View Product |
| Gene knockdown (AAV) | VS412684 | View Product | |
| ORF Vector | Template DNA | PC412684 | View Product |
| Template DNA | PC512684 | View Product |
Rat Atp2a2 Gene Overview
| Gene Name | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
|---|---|
| Gene Symbol | Atp2a2 |
| Synonyms | Serca2,SercaII |
| NCBI ID | 29693 |
| Ensembl ID | ENSRNOG00000001285 |
| Uniprot ID | P11507 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including ATP binding activity; P-type calcium transporter activity; and lutropin-choriogonadotropic hormone receptor binding activity. Involved in several processes, including calcium ion transport; regulation of cardiac muscle cell membrane potential; and regulation of cardiac muscle contraction. Located in several cellular components, including apical ectoplasmic specialization; perinuclear region of cytoplasm; and sarcoplasmic reticulum. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study abdominal obesity-metabolic syndrome 1; congestive heart failure; and type 2 diabetes mellitus. Biomarker of euthyroid sick syndrome; heart disease; hypothyroidism; pulmonary hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Atp2a2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC612684 | View Product |
| Stable overexpression | LC712684 | View Product | |
| AAV Vector & Virus | Long-term expression | VC612684 | View Product |
| Long-term expression | VC712684 | View Product | |
| Adenovirus | Transient expression | A612684 | View Product |
| Transient expression | A712684 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG612684 | View Product |
| Gene knockout (non-viral) | PG612684 | View Product | |
| Gene knockout (AAV) | VG612684 | View Product | |
| CRISPR Activation | Gene activation | LA612684 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS612684 | View Product |
| Gene knockdown (AAV) | VS612684 | View Product | |
| ORF Vector | Template DNA | PC612684 | View Product |
| Template DNA | PC712684 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |