ATRX Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ATRX-specific vectors and viral particles designed for reliable ATRX overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ATRX CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ATRX Gene Overview
| Gene Name | ATRX chromatin remodeler |
|---|---|
| Gene Symbol | ATRX |
| Synonyms | JMS,XH2,XNP,MRX52,RAD54,RAD54L,ZNF-HX |
| NCBI ID | 546 |
| Ensembl ID | ENSG00000085224 |
| Uniprot ID | P46100 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Human ATRX Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG112837 | View Product |
| Gene knockout (non-viral) | PG112837 | View Product | |
| Gene knockout (AAV) | VG112837 | View Product | |
| CRISPR Activation | Gene activation | LA112837 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS112837 | View Product |
| Gene knockdown (AAV) | VS112837 | View Product | |
| ORF Vector | Template DNA | PC112837 | View Product |
Mouse Atrx Gene Overview
| Gene Name | ATRX, chromatin remodeler |
|---|---|
| Gene Symbol | Atrx |
| Synonyms | XH2,Xnp,ATR2,MRXS3,Rad54,Hp1bp2,RAD54L,ZNF-HX,Hp1bp38,HP1-BP38,DXHXS6677E,4833408C14Rik |
| NCBI ID | 22589 |
| Ensembl ID | ENSMUSG00000031229 |
| Uniprot ID | Q61687 |
| Gene Type | Protein coding |
Gene Summary
Enables chromatin binding activity and histone binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; cellular response to hydroxyurea; and positive regulation of DNA metabolic process. Acts upstream of or within several processes, including male gonad development; positive regulation of transcription by RNA polymerase II; and post-embryonic forelimb morphogenesis. Located in PML body and chromosome. Colocalizes with chromosome, telomeric region. Is expressed in several structures, including alimentary system; early embryo; egg cylinder; genitourinary system; and nervous system. Used to study alpha thalassemia-X-linked intellectual disability syndrome. Human ortholog(s) of this gene implicated in X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; alpha-thalassemia myelodysplasia syndrome; high grade glioma; and lung small cell carcinoma. Orthologous to human ATRX (ATRX chromatin remodeler). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Atrx Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG412837 | View Product |
| Gene knockout (non-viral) | PG412837 | View Product | |
| Gene knockout (AAV) | VG412837 | View Product | |
| CRISPR Activation | Gene activation | LA412837 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS412837 | View Product |
| Gene knockdown (AAV) | VS412837 | View Product | |
| ORF Vector | Template DNA | PC412837 | View Product |
Rat Atrx Gene Overview
| Gene Name | ATRX, chromatin remodeler |
|---|---|
| Gene Symbol | Atrx |
| Synonyms | Xnp |
| NCBI ID | 246284 |
| Ensembl ID | ENSRNOG00000056703 |
| Uniprot ID | P70486 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including DNA translocase activity; chromo shadow domain binding activity; and methylated histone binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; chromatin remodeling; and positive regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within several processes, including male gonad development; meiotic spindle organization; and post-embryonic forelimb morphogenesis. Predicted to be located in several cellular components, including chromosomal region; ciliary basal body; and nuclear lumen. Human ortholog(s) of this gene implicated in X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; alpha-thalassemia myelodysplasia syndrome; high grade glioma; and lung small cell carcinoma. Orthologous to human ATRX (ATRX chromatin remodeler). [provided by Alliance of Genome Resources, Apr 2025]
Rat Atrx Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |