AXIN1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use AXIN1-specific vectors and viral particles designed for reliable AXIN1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including AXIN1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human AXIN1 Gene Overview
| Gene Name | axin 1 |
|---|---|
| Gene Symbol | AXIN1 |
| Synonyms | AXIN,CMDOH,PPP1R49 |
| NCBI ID | 8312 |
| Ensembl ID | ENSG00000103126 |
| Uniprot ID | O15169 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Human AXIN1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC112897 | View Product |
| AAV Vector & Virus | Long-term expression | VC112897 | View Product |
| Adenovirus | Transient expression | A112897 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG112897 | View Product |
| Gene knockout (non-viral) | PG112897 | View Product | |
| Gene knockout (AAV) | VG112897 | View Product | |
| CRISPR Activation | Gene activation | LA112897 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS112897 | View Product |
| Gene knockdown (AAV) | VS112897 | View Product | |
| ORF Vector | Template DNA | PC112897 | View Product |
Mouse Axin1 Gene Overview
| Gene Name | axin 1 |
|---|---|
| Gene Symbol | Axin1 |
| Synonyms | Fu,Kb,Ki,Axin,fused,kinky,knobbly |
| NCBI ID | 12005 |
| Ensembl ID | ENSMUSG00000024182 |
| Uniprot ID | O35625 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in negative regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; and positive regulation of protein kinase activity. Acts upstream of or within several processes, including chordate embryonic development; regulation of Wnt signaling pathway; and regulation of macromolecule metabolic process. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and microtubule cytoskeleton. Part of Wnt signalosome and beta-catenin destruction complex. Is expressed in several structures, including eye; forebrain; genitourinary system; hemolymphoid system gland; and jaw. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and urinary bladder cancer. Orthologous to human AXIN1 (axin 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Axin1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC412897 | View Product |
| Stable overexpression | LC512897 | View Product | |
| AAV Vector & Virus | Long-term expression | VC412897 | View Product |
| Long-term expression | VC512897 | View Product | |
| Adenovirus | Transient expression | A412897 | View Product |
| siRNA Tools | Gene knockdown (AAV) | VS412897 | View Product |
| ORF Vector | Template DNA | PC412897 | View Product |
| Template DNA | PC512897 | View Product |
Rat Axin1 Gene Overview
| Gene Name | axin 1 |
|---|---|
| Gene Symbol | Axin1 |
| Synonyms | Axin,axin-1 |
| NCBI ID | 79257 |
| Ensembl ID | ENSRNOG00000062714 |
| Uniprot ID | O70239 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including armadillo repeat domain binding activity; beta-catenin binding activity; and identical protein binding activity. Involved in negative regulation of canonical Wnt signaling pathway; positive regulation of protein metabolic process; and response to quercetin. Located in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. Part of beta-catenin destruction complex. Is active in synapse. Biomarker of colon cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and urinary bladder cancer. Orthologous to human AXIN1 (axin 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Axin1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC612897 | View Product |
| AAV Vector & Virus | Long-term expression | VC612897 | View Product |
| Adenovirus | Transient expression | A612897 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG612897 | View Product |
| Gene knockout (non-viral) | PG612897 | View Product | |
| Gene knockout (AAV) | VG612897 | View Product | |
| CRISPR Activation | Gene activation | LA612897 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS612897 | View Product |
| Gene knockdown (AAV) | VS612897 | View Product | |
| ORF Vector | Template DNA | PC612897 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |