B2M Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use B2M-specific vectors and viral particles designed for reliable B2M overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including B2M CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human B2M Gene Overview
| Gene Name | beta-2-microglobulin |
|---|---|
| Gene Symbol | B2M |
| Synonyms | IMD43,AMYLD6,MHC1D4 |
| NCBI ID | 567 |
| Ensembl ID | ENSG00000166710 |
| Uniprot ID | P61769 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
Human B2M Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC112922 | View Product |
| AAV Vector & Virus | Long-term expression | VC112922 | View Product |
| Adenovirus | Transient expression | A112922 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG112922 | View Product |
| Gene knockout (non-viral) | PG112922 | View Product | |
| Gene knockout (AAV) | VG112922 | View Product | |
| CRISPR Activation | Gene activation | LA112922 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS112922 | View Product |
| Gene knockdown (AAV) | VS112922 | View Product | |
| ORF Vector | Template DNA | PC112922 | View Product |
Mouse B2m Gene Overview
| Gene Name | beta-2 microglobulin |
|---|---|
| Gene Symbol | B2m |
| Synonyms | Ly-m11,beta2m,beta2-m |
| NCBI ID | 12010 |
| Ensembl ID | ENSMUSG00000060802 |
| Uniprot ID | P01887 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including MHC class II protein complex binding activity; peptide antigen binding activity; and protein homodimerization activity. Involved in learning or memory; negative regulation of cell differentiation; and sensory perception of smell. Acts upstream of or within several processes, including antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cellular response to iron(III) ion; and multicellular organismal-level iron ion homeostasis. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Used to study hemochromatosis. Human ortholog(s) of this gene implicated in arthritis; immunodeficiency 43; and inflammatory bowel disease. Orthologous to human B2M (beta-2-microglobulin). [provided by Alliance of Genome Resources, Jul 2025]
Mouse B2m Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC412922 | View Product |
| AAV Vector & Virus | Long-term expression | VC412922 | View Product |
| Adenovirus | Transient expression | A412922 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG412922 | View Product |
| Gene knockout (non-viral) | PG412922 | View Product | |
| Gene knockout (AAV) | VG412922 | View Product | |
| CRISPR Activation | Gene activation | LA412922 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS412922 | View Product |
| Gene knockdown (AAV) | VS412922 | View Product | |
| ORF Vector | Template DNA | PC412922 | View Product |
Rat B2m Gene Overview
| Gene Name | beta-2 microglobulin |
|---|---|
| Gene Symbol | B2m |
| Synonyms | |
| NCBI ID | 24223 |
| Ensembl ID | ENSRNOG00000017123 |
| Uniprot ID | P07151 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including MHC class II protein complex binding activity; peptide antigen binding activity; and protein homodimerization activity. Involved in response to cadmium ion and response to xenobiotic stimulus. Located in extracellular space. Biomarker of acute kidney failure; pyelonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in arthritis; immunodeficiency 43; and inflammatory bowel disease. Orthologous to human B2M (beta-2-microglobulin). [provided by Alliance of Genome Resources, Jul 2025]
Rat B2m Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC612922 | View Product |
| AAV Vector & Virus | Long-term expression | VC612922 | View Product |
| Adenovirus | Transient expression | A612922 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG612922 | View Product |
| Gene knockout (non-viral) | PG612922 | View Product | |
| Gene knockout (AAV) | VG612922 | View Product | |
| CRISPR Activation | Gene activation | LA612922 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS612922 | View Product |
| Gene knockdown (AAV) | VS612922 | View Product | |
| ORF Vector | Template DNA | PC612922 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |