BCL2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use BCL2-specific vectors and viral particles designed for reliable BCL2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including BCL2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human BCL2 Gene Overview
| Gene Name | BCL2 apoptosis regulator |
|---|---|
| Gene Symbol | BCL2 |
| Synonyms | Bcl-2,PPP1R50 |
| NCBI ID | 596 |
| Ensembl ID | ENSG00000171791 |
| Uniprot ID | P10415 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Human BCL2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC113225 | View Product |
| AAV Vector & Virus | Long-term expression | VC113225 | View Product |
| Adenovirus | Transient expression | A213225 | View Product |
| Transient expression | A313225 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG113225 | View Product |
| Gene knockout (non-viral) | PG113225 | View Product | |
| Gene knockout (AAV) | VG113225 | View Product | |
| CRISPR Activation | Gene activation | LA113225 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS113225 | View Product |
| Gene knockdown (AAV) | VS113225 | View Product | |
| ORF Vector | Template DNA | PC113225 | View Product |
Mouse Bcl2 Gene Overview
| Gene Name | B cell leukemia/lymphoma 2 |
|---|---|
| Gene Symbol | Bcl2 |
| Synonyms | Bcl-2,C430015F12Rik,D630044D05Rik,D830018M01Rik |
| NCBI ID | 12043 |
| Ensembl ID | ENSMUSG00000057329 |
| Uniprot ID | P10417 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Mouse Bcl2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC413225 | View Product |
| Stable overexpression | LC513225 | View Product | |
| AAV Vector & Virus | Long-term expression | VC413225 | View Product |
| Long-term expression | VC513225 | View Product | |
| Adenovirus | Transient expression | A413225 | View Product |
| Transient expression | A513225 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG413225 | View Product |
| Gene knockout (non-viral) | PG413225 | View Product | |
| Gene knockout (AAV) | VG413225 | View Product | |
| CRISPR Activation | Gene activation | LA413225 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS413225 | View Product |
| Gene knockdown (AAV) | VS413225 | View Product | |
| ORF Vector | Template DNA | PC413225 | View Product |
| Template DNA | PC513225 | View Product |
Rat Bcl2 Gene Overview
| Gene Name | BCL2, apoptosis regulator |
|---|---|
| Gene Symbol | Bcl2 |
| Synonyms | Bcl-2 |
| NCBI ID | 24224 |
| Ensembl ID | ENSRNOG00000077679 |
| Uniprot ID | P49950 |
| Gene Type | Protein coding |
Gene Summary
Enables BH domain binding activity. Involved in several processes, including cellular response to L-glutamate; central nervous system development; and response to monosaccharide. Located in mitochondrial crista and perinuclear region of cytoplasm. Used to study several diseases, including brain ischemia (multiple); end stage renal disease; gastric ulcer; intestinal disease (multiple); and status epilepticus. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); carcinoma (multiple); intrinsic cardiomyopathy (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2025]
Rat Bcl2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC613225 | View Product |
| AAV Vector & Virus | Long-term expression | VC613225 | View Product |
| Adenovirus | Transient expression | A613225 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG613225 | View Product |
| Gene knockout (non-viral) | PG613225 | View Product | |
| Gene knockout (AAV) | VG613225 | View Product | |
| CRISPR Activation | Gene activation | LA613225 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS613225 | View Product |
| Gene knockdown (AAV) | VS613225 | View Product | |
| ORF Vector | Template DNA | PC613225 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |