BIRC5 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use BIRC5-specific vectors and viral particles designed for reliable BIRC5 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including BIRC5 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human BIRC5 Gene Overview
| Gene Name | baculoviral IAP repeat containing 5 |
|---|---|
| Gene Symbol | BIRC5 |
| Synonyms | API4,EPR-1 |
| NCBI ID | 332 |
| Ensembl ID | ENSG00000089685 |
| Uniprot ID | O15392 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Human BIRC5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC113331 | View Product |
| AAV Vector & Virus | Long-term expression | VC113331 | View Product |
| Adenovirus | Transient expression | A213331 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG113331 | View Product |
| Gene knockout (non-viral) | PG113331 | View Product | |
| Gene knockout (AAV) | VG113331 | View Product | |
| CRISPR Activation | Gene activation | LA113331 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS113331 | View Product |
| Gene knockdown (AAV) | VS113331 | View Product | |
| ORF Vector | Template DNA | PC113331 | View Product |
Mouse Birc5 Gene Overview
| Gene Name | baculoviral IAP repeat-containing 5 |
|---|---|
| Gene Symbol | Birc5 |
| Synonyms | Api4,TIAP,AAC-11,survivin40 |
| NCBI ID | 11799 |
| Ensembl ID | ENSMUSG00000017716 |
| Uniprot ID | O70201 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]
Mouse Birc5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC413331 | View Product |
| Stable overexpression | LC513331 | View Product | |
| AAV Vector & Virus | Long-term expression | VC413331 | View Product |
| Long-term expression | VC513331 | View Product | |
| Adenovirus | Transient expression | A413331 | View Product |
| Transient expression | A513331 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG413331 | View Product |
| Gene knockout (non-viral) | PG413331 | View Product | |
| Gene knockout (AAV) | VG413331 | View Product | |
| CRISPR Activation | Gene activation | LA413331 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS413331 | View Product |
| Gene knockdown (AAV) | VS413331 | View Product | |
| ORF Vector | Template DNA | PC413331 | View Product |
| Template DNA | PC513331 | View Product |
Rat Birc5 Gene Overview
| Gene Name | baculoviral IAP repeat-containing 5 |
|---|---|
| Gene Symbol | Birc5 |
| Synonyms | AP14 |
| NCBI ID | 64041 |
| Ensembl ID | ENSRNOG00000050819 |
| Uniprot ID | Q9JHY7 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein dimerization activity; and small GTPase binding activity. Involved in several processes, including cellular response to ethanol; cellular response to stem cell factor stimulus; and response to glucocorticoid. Located in apical plasma membrane. Used to study endometriosis and pulmonary hypertension. Biomarker of acute pancreatitis (multiple); artery disease (multiple); congestive heart failure; high grade glioma; and stomach carcinoma. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Rat Birc5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC613331 | View Product |
| AAV Vector & Virus | Long-term expression | VC613331 | View Product |
| Adenovirus | Transient expression | A613331 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG613331 | View Product |
| Gene knockout (non-viral) | PG613331 | View Product | |
| Gene knockout (AAV) | VG613331 | View Product | |
| CRISPR Activation | Gene activation | LA613331 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS613331 | View Product |
| Gene knockdown (AAV) | VS613331 | View Product | |
| ORF Vector | Template DNA | PC613331 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |