BMI1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use BMI1-specific vectors and viral particles designed for reliable BMI1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including BMI1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human BMI1 Gene Overview
| Gene Name | BMI1 proto-oncogene, polycomb ring finger |
|---|---|
| Gene Symbol | BMI1 |
| Synonyms | PCGF4,RNF51,FLVI2/BMI1,flvi-2/bmi-1 |
| NCBI ID | 648 |
| Ensembl ID | ENSG00000168283 |
| Uniprot ID | P35226 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
Human BMI1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC113353 | View Product |
| AAV Vector & Virus | Long-term expression | VC113353 | View Product |
| Adenovirus | Transient expression | A113353 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG113353 | View Product |
| Gene knockout (non-viral) | PG113353 | View Product | |
| Gene knockout (AAV) | VG113353 | View Product | |
| CRISPR Activation | Gene activation | LA113353 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS113353 | View Product |
| Gene knockdown (AAV) | VS113353 | View Product | |
| ORF Vector | Template DNA | PC113353 | View Product |
Mouse Bmi1 Gene Overview
| Gene Name | Bmi1 proto-oncogene, polycomb ring finger |
|---|---|
| Gene Symbol | Bmi1 |
| Synonyms | Bmi-1,Pcgf4 |
| NCBI ID | 12151 |
| Ensembl ID | ENSMUSG00000026739 |
| Uniprot ID | P25916 |
| Gene Type | Protein coding |
Gene Summary
Enables promoter-specific chromatin binding activity and ubiquitin-protein transferase activator activity. Involved in positive regulation of B cell proliferation and positive regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule biosynthetic process; and regulation of adaxial/abaxial pattern formation. Located in heterochromatin and nuclear body. Part of PRC1 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Bmi1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC413353 | View Product |
| AAV Vector & Virus | Long-term expression | VC413353 | View Product |
| Adenovirus | Transient expression | A413353 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG413353 | View Product |
| Gene knockout (non-viral) | PG413353 | View Product | |
| Gene knockout (AAV) | VG413353 | View Product | |
| CRISPR Activation | Gene activation | LA413353 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS413353 | View Product |
| Gene knockdown (AAV) | VS413353 | View Product | |
| ORF Vector | Template DNA | PC413353 | View Product |
Rat Bmi1 Gene Overview
| Gene Name | BMI1 proto-oncogene, polycomb ring finger |
|---|---|
| Gene Symbol | Bmi1 |
| Synonyms | Pcgf4 |
| NCBI ID | 307151 |
| Ensembl ID | ENSRNOG00000016585 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including RING-like zinc finger domain binding activity; promoter-specific chromatin binding activity; and zinc ion binding activity. Involved in cellular response to dexamethasone stimulus; cellular response to interleukin-1; and regulation of kidney development. Predicted to be located in cytosol; heterochromatin; and nuclear body. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger). [provided by Alliance of Genome Resources, Jul 2025]
Rat Bmi1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC613353 | View Product |
| AAV Vector & Virus | Long-term expression | VC613353 | View Product |
| Adenovirus | Transient expression | A613353 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG613353 | View Product |
| Gene knockout (non-viral) | PG613353 | View Product | |
| Gene knockout (AAV) | VG613353 | View Product | |
| CRISPR Activation | Gene activation | LA613353 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS613353 | View Product |
| Gene knockdown (AAV) | VS613353 | View Product | |
| ORF Vector | Template DNA | PC613353 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |