BRCA1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use BRCA1-specific vectors and viral particles designed for reliable BRCA1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including BRCA1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human BRCA1 Gene Overview
| Gene Name | BRCA1 DNA repair associated |
|---|---|
| Gene Symbol | BRCA1 |
| Synonyms | IRIS,PSCP,BRCAI,BRCC1,FANCS,PNCA4,RNF53,BROVCA1,PPP1R53 |
| NCBI ID | 672 |
| Ensembl ID | ENSG00000012048 |
| Uniprot ID | P38398 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]
Human BRCA1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC113452 | View Product |
| AAV Vector & Virus | Long-term expression | VC113452 | View Product |
| Adenovirus | Transient expression | A213452 | View Product |
| Transient expression | A313452 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG113452 | View Product |
| Gene knockout (non-viral) | PG113452 | View Product | |
| Gene knockout (AAV) | VG113452 | View Product | |
| CRISPR Activation | Gene activation | LA113452 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS113452 | View Product |
| Gene knockdown (AAV) | VS113452 | View Product | |
| ORF Vector | Template DNA | PC113452 | View Product |
| Template DNA | PC213452 | View Product |
Mouse Brca1 Gene Overview
| Gene Name | breast cancer 1, early onset |
|---|---|
| Gene Symbol | Brca1 |
| Synonyms | |
| NCBI ID | 12189 |
| Ensembl ID | ENSMUSG00000017146 |
| Uniprot ID | P48754 |
| Gene Type | Protein coding |
Gene Summary
Enables damaged DNA binding activity; transcription cis-regulatory region binding activity; and transcription coactivator activity. Involved in double-strand break repair and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within several processes, including centrosome cycle; mitotic G2/M transition checkpoint; and random inactivation of X chromosome. Located in chromosome; cytoplasm; and male germ cell nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Used to study breast cancer; hereditary breast ovarian cancer syndrome; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group S; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Brca1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A413452 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG413452 | View Product |
| Gene knockout (non-viral) | PG413452 | View Product | |
| Gene knockout (AAV) | VG413452 | View Product | |
| CRISPR Activation | Gene activation | LA413452 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS413452 | View Product |
| Gene knockdown (AAV) | VS413452 | View Product | |
| ORF Vector | Template DNA | PC413452 | View Product |
Rat Brca1 Gene Overview
| Gene Name | BRCA1, DNA repair associated |
|---|---|
| Gene Symbol | Brca1 |
| Synonyms | BRCA-1 |
| NCBI ID | 497672 |
| Ensembl ID | ENSRNOG00000020701 |
| Uniprot ID | O54952 |
| Gene Type | Protein coding |
Gene Summary
Enables chromatin binding activity. Involved in several processes, including positive regulation of protein import into nucleus; response to estradiol; and response to genistein. Located in mitochondrial matrix. Biomarker of ductal carcinoma in situ. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group S; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated). [provided by Alliance of Genome Resources, Jul 2025]
Rat Brca1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A613452 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG613452 | View Product |
| Gene knockout (non-viral) | PG613452 | View Product | |
| Gene knockout (AAV) | VG613452 | View Product | |
| CRISPR Activation | Gene activation | LA613452 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS613452 | View Product |
| Gene knockdown (AAV) | VS613452 | View Product | |
| ORF Vector | Template DNA | PC613452 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |