BRD4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use BRD4-specific vectors and viral particles designed for reliable BRD4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including BRD4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human BRD4 Gene Overview
| Gene Name | bromodomain containing 4 |
|---|---|
| Gene Symbol | BRD4 |
| Synonyms | CAP,MCAP,CDLS6,HUNK1,HUNKI,FSHRG4 |
| NCBI ID | 23476 |
| Ensembl ID | ENSG00000141867 |
| Uniprot ID | O60885 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Human BRD4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC113461 | View Product |
| Adenovirus | Transient expression | A113461 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG113461 | View Product |
| Gene knockout (non-viral) | PG113461 | View Product | |
| Gene knockout (AAV) | VG113461 | View Product | |
| CRISPR Activation | Gene activation | LA113461 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS113461 | View Product |
| Gene knockdown (AAV) | VS113461 | View Product | |
| ORF Vector | Template DNA | PC113461 | View Product |
Mouse Brd4 Gene Overview
| Gene Name | bromodomain containing 4 |
|---|---|
| Gene Symbol | Brd4 |
| Synonyms | Brd5,MCAP,HUNK1,WI-11513 |
| NCBI ID | 57261 |
| Ensembl ID | ENSMUSG00000024002 |
| Uniprot ID | Q9ESU6 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including RNA polymerase II C-terminal domain binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of T-helper 17 cell lineage commitment. Acts upstream of or within chromosome segregation; inner cell mass cell proliferation; and protein autophosphorylation. Located in chromatin and condensed nuclear chromosome. Part of cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; pancreas; and sensory organ. Used to study nephrocalcinosis. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 6; colon cancer; and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Brd4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC413461 | View Product |
| Stable overexpression | LC513461 | View Product | |
| AAV Vector & Virus | Long-term expression | VC413461 | View Product |
| Adenovirus | Transient expression | A413461 | View Product |
| Transient expression | A513461 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG413461 | View Product |
| Gene knockout (non-viral) | PG413461 | View Product | |
| Gene knockout (AAV) | VG413461 | View Product | |
| CRISPR Activation | Gene activation | LA413461 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS413461 | View Product |
| Gene knockdown (AAV) | VS413461 | View Product | |
| ORF Vector | Template DNA | PC413461 | View Product |
| Template DNA | PC513461 | View Product |
Rat Brd4 Gene Overview
| Gene Name | bromodomain containing 4 |
|---|---|
| Gene Symbol | Brd4 |
| Synonyms | |
| NCBI ID | 362844 |
| Ensembl ID | ENSRNOG00000006770 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including P-TEFb complex binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Involved in cellular response to glucose stimulus. Predicted to be located in condensed nuclear chromosome and nucleoplasm. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 6; colon cancer; and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Apr 2025]
Rat Brd4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC613461 | View Product |
| Adenovirus | Transient expression | A613461 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG613461 | View Product |
| Gene knockout (non-viral) | PG613461 | View Product | |
| Gene knockout (AAV) | VG613461 | View Product | |
| CRISPR Activation | Gene activation | LA613461 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS613461 | View Product |
| Gene knockdown (AAV) | VS613461 | View Product | |
| ORF Vector | Template DNA | PC613461 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |