CBFB Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CBFB-specific vectors and viral particles designed for reliable CBFB overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CBFB CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CBFB Gene Overview
| Gene Name | core-binding factor subunit beta |
|---|---|
| Gene Symbol | CBFB |
| Synonyms | CLCD2,PEBP2B |
| NCBI ID | 865 |
| Ensembl ID | ENSG00000067955 |
| Uniprot ID | Q13951 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Human CBFB Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC215104 | View Product |
| AAV Vector & Virus | Long-term expression | VC115104 | View Product |
| Adenovirus | Transient expression | A115104 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115104 | View Product |
| Gene knockout (non-viral) | PG115104 | View Product | |
| Gene knockout (AAV) | VG115104 | View Product | |
| CRISPR Activation | Gene activation | LA115104 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115104 | View Product |
| Gene knockdown (AAV) | VS115104 | View Product | |
| ORF Vector | Template DNA | PC115104 | View Product |
Mouse Cbfb Gene Overview
| Gene Name | core binding factor beta |
|---|---|
| Gene Symbol | Cbfb |
| Synonyms | PEA2,Pebp2,PEBP2b,Pebpb2 |
| NCBI ID | 12400 |
| Ensembl ID | ENSMUSG00000031885 |
| Uniprot ID | Q08024 |
| Gene Type | Protein coding |
Gene Summary
Contributes to sequence-specific DNA binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of CD8-positive, alpha-beta T cell differentiation. Acts upstream of or within several processes, including hemopoiesis; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Cbfb Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415104 | View Product |
| Stable overexpression | LC515104 | View Product | |
| AAV Vector & Virus | Long-term expression | VC415104 | View Product |
| Long-term expression | VC515104 | View Product | |
| Adenovirus | Transient expression | A415104 | View Product |
| Transient expression | A515104 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415104 | View Product |
| Gene knockout (non-viral) | PG415104 | View Product | |
| Gene knockout (AAV) | VG415104 | View Product | |
| CRISPR Activation | Gene activation | LA415104 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415104 | View Product |
| Gene knockdown (AAV) | VS415104 | View Product | |
| ORF Vector | Template DNA | PC415104 | View Product |
| Template DNA | PC515104 | View Product |
Rat Cbfb Gene Overview
| Gene Name | core-binding factor subunit beta |
|---|---|
| Gene Symbol | Cbfb |
| Synonyms | Pebp2 |
| NCBI ID | 361391 |
| Ensembl ID | ENSRNOG00000014647 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; protein polyubiquitination; and regulation of alpha-beta T cell differentiation. Predicted to act upstream of or within several processes, including hemopoiesis; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core-binding activity factor complex. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Rat Cbfb Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615104 | View Product |
| AAV Vector & Virus | Long-term expression | VC615104 | View Product |
| Adenovirus | Transient expression | A615104 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615104 | View Product |
| Gene knockout (non-viral) | PG615104 | View Product | |
| Gene knockout (AAV) | VG615104 | View Product | |
| CRISPR Activation | Gene activation | LA615104 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615104 | View Product |
| Gene knockdown (AAV) | VS615104 | View Product | |
| ORF Vector | Template DNA | PC615104 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |