CCL2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CCL2-specific vectors and viral particles designed for reliable CCL2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CCL2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CCL2 Gene Overview
| Gene Name | C-C motif chemokine ligand 2 |
|---|---|
| Gene Symbol | CCL2 |
| Synonyms | HC11,MCAF,MCP1,MCP-1,SCYA2,GDCF-2,SMC-CF,HSMCR30 |
| NCBI ID | 6347 |
| Ensembl ID | ENSG00000108691 |
| Uniprot ID | P13500 |
| Gene Type | Protein coding |
Gene Summary
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]
Human CCL2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115352 | View Product |
| AAV Vector & Virus | Long-term expression | VC115352 | View Product |
| Adenovirus | Transient expression | A115352 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115352 | View Product |
| Gene knockout (non-viral) | PG115352 | View Product | |
| Gene knockout (AAV) | VG115352 | View Product | |
| CRISPR Activation | Gene activation | LA115352 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115352 | View Product |
| Gene knockdown (AAV) | VS115352 | View Product | |
| ORF Vector | Template DNA | PC115352 | View Product |
Mouse Ccl2 Gene Overview
| Gene Name | C-C motif chemokine ligand 2 |
|---|---|
| Gene Symbol | Ccl2 |
| Synonyms | JE,HC11,MCAF,MCP1,MCP-1,Scya2,Sigje,SMC-CF |
| NCBI ID | 20296 |
| Ensembl ID | ENSMUSG00000035385 |
| Uniprot ID | P10148 |
| Gene Type | Protein coding |
Gene Summary
This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015]
Mouse Ccl2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415352 | View Product |
| AAV Vector & Virus | Long-term expression | VC415352 | View Product |
| Adenovirus | Transient expression | A415352 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415352 | View Product |
| Gene knockout (non-viral) | PG415352 | View Product | |
| Gene knockout (AAV) | VG415352 | View Product | |
| CRISPR Activation | Gene activation | LA415352 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415352 | View Product |
| Gene knockdown (AAV) | VS415352 | View Product | |
| ORF Vector | Template DNA | PC415352 | View Product |
Rat Ccl2 Gene Overview
| Gene Name | C-C motif chemokine ligand 2 |
|---|---|
| Gene Symbol | Ccl2 |
| Synonyms | MCP1,MCP-1,Scya2,Sigje |
| NCBI ID | 24770 |
| Ensembl ID | ENSRNOG00000007159 |
| Uniprot ID | P14844 |
| Gene Type | Protein coding |
Gene Summary
Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of leukocyte migration. Located in several cellular components, including axon; perikaryon; and perinuclear region of cytoplasm. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); liver disease (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA vasculitis; aggressive periodontitis; autoimmune disease (multiple); end stage renal disease; and gastrointestinal system cancer (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ccl2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615352 | View Product |
| AAV Vector & Virus | Long-term expression | VC615352 | View Product |
| Adenovirus | Transient expression | A615352 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615352 | View Product |
| Gene knockout (non-viral) | PG615352 | View Product | |
| Gene knockout (AAV) | VG615352 | View Product | |
| CRISPR Activation | Gene activation | LA615352 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615352 | View Product |
| Gene knockdown (AAV) | VS615352 | View Product | |
| ORF Vector | Template DNA | PC615352 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |