CCL5 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CCL5-specific vectors and viral particles designed for reliable CCL5 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CCL5 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CCL5 Gene Overview
| Gene Name | C-C motif chemokine ligand 5 |
|---|---|
| Gene Symbol | CCL5 |
| Synonyms | SISd,eoCP,SCYA5,RANTES,TCP228,D17S136E,SIS-delta |
| NCBI ID | 6352 |
| Ensembl ID | ENSG00000271503 |
| Uniprot ID | P13501 |
| Gene Type | Protein coding |
Gene Summary
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Human CCL5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115374 | View Product |
| AAV Vector & Virus | Long-term expression | VC115374 | View Product |
| Adenovirus | Transient expression | A115374 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115374 | View Product |
| Gene knockout (non-viral) | PG115374 | View Product | |
| Gene knockout (AAV) | VG115374 | View Product | |
| CRISPR Activation | Gene activation | LA115374 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115374 | View Product |
| Gene knockdown (AAV) | VS115374 | View Product | |
| ORF Vector | Template DNA | PC115374 | View Product |
Mouse Ccl5 Gene Overview
| Gene Name | C-C motif chemokine ligand 5 |
|---|---|
| Gene Symbol | Ccl5 |
| Synonyms | SISd,Scya5,RANTES,TCP228,MuRantes |
| NCBI ID | 20304 |
| Ensembl ID | ENSMUSG00000035042 |
| Uniprot ID | P30882 |
| Gene Type | Protein coding |
Gene Summary
Enables CCR1 chemokine receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Ccl5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415374 | View Product |
| AAV Vector & Virus | Long-term expression | VC415374 | View Product |
| Adenovirus | Transient expression | A415374 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415374 | View Product |
| Gene knockout (non-viral) | PG415374 | View Product | |
| Gene knockout (AAV) | VG415374 | View Product | |
| CRISPR Activation | Gene activation | LA415374 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415374 | View Product |
| Gene knockdown (AAV) | VS415374 | View Product | |
| ORF Vector | Template DNA | PC415374 | View Product |
Rat Ccl5 Gene Overview
| Gene Name | C-C motif chemokine ligand 5 |
|---|---|
| Gene Symbol | Ccl5 |
| Synonyms | Scya5,Rantes |
| NCBI ID | 81780 |
| Ensembl ID | ENSRNOG00000047940 |
| Uniprot ID | P50231 |
| Gene Type | Protein coding |
Gene Summary
Enables chemokine activity and heparin binding activity. Involved in several processes, including lymphocyte migration; positive regulation of cell differentiation; and positive regulation of leukocyte chemotaxis. Located in extracellular space. Used to study Chagas disease; bronchiolitis obliterans; kidney disease; metabolic dysfunction-associated steatotic liver disease; and orchitis. Biomarker of several diseases, including artery disease (multiple); cardiac arrest; liver disease (multiple); lung disease (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5). [provided by Alliance of Genome Resources, Apr 2025]
Rat Ccl5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615374 | View Product |
| AAV Vector & Virus | Long-term expression | VC615374 | View Product |
| Adenovirus | Transient expression | A615374 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615374 | View Product |
| Gene knockout (non-viral) | PG615374 | View Product | |
| Gene knockout (AAV) | VG615374 | View Product | |
| CRISPR Activation | Gene activation | LA615374 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615374 | View Product |
| Gene knockdown (AAV) | VS615374 | View Product | |
| ORF Vector | Template DNA | PC615374 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |