CCR5 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CCR5-specific vectors and viral particles designed for reliable CCR5 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CCR5 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CCR5 Gene Overview
| Gene Name | C-C motif chemokine receptor 5 |
|---|---|
| Gene Symbol | CCR5 |
| Synonyms | CKR5,CCR-5,CD195,CKR-5,CCCKR5,CMKBR5,IDDM22,CC-CKR-5 |
| NCBI ID | 1234 |
| Ensembl ID | ENSG00000160791 |
| Uniprot ID | P51681 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
Human CCR5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115429 | View Product |
| AAV Vector & Virus | Long-term expression | VC115429 | View Product |
| Adenovirus | Transient expression | A115429 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115429 | View Product |
| Gene knockout (non-viral) | PG115429 | View Product | |
| Gene knockout (AAV) | VG115429 | View Product | |
| CRISPR Activation | Gene activation | LA115429 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115429 | View Product |
| Gene knockdown (AAV) | VS115429 | View Product | |
| ORF Vector | Template DNA | PC115429 | View Product |
Mouse Ccr5 Gene Overview
| Gene Name | C-C motif chemokine receptor 5 |
|---|---|
| Gene Symbol | Ccr5 |
| Synonyms | AM4-7,CD195,Cmkbr5 |
| NCBI ID | 12774 |
| Ensembl ID | ENSMUSG00000079227 |
| Uniprot ID | P51682 |
| Gene Type | Protein coding |
Gene Summary
Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in negative regulation of macrophage apoptotic process. Acts upstream of or within apoptotic process and defense response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif chemokine receptor 5). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Ccr5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415429 | View Product |
| AAV Vector & Virus | Long-term expression | VC415429 | View Product |
| Adenovirus | Transient expression | A415429 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415429 | View Product |
| Gene knockout (non-viral) | PG415429 | View Product | |
| Gene knockout (AAV) | VG415429 | View Product | |
| CRISPR Activation | Gene activation | LA415429 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415429 | View Product |
| Gene knockdown (AAV) | VS415429 | View Product | |
| ORF Vector | Template DNA | PC415429 | View Product |
Rat Ccr5 Gene Overview
| Gene Name | C-C motif chemokine receptor 5 |
|---|---|
| Gene Symbol | Ccr5 |
| Synonyms | Ckr5,Cmkbr5 |
| NCBI ID | 117029 |
| Ensembl ID | ENSRNOG00000049115 |
| Uniprot ID | O08556 |
| Gene Type | Protein coding |
Gene Summary
Enables protein kinase binding activity. Involved in several processes, including negative regulation of axon extension; positive regulation of cytokine production; and response to bacterium. Located in cell surface and endosome. Used to study Alzheimer's disease and plague. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; orchitis; and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif chemokine receptor 5). [provided by Alliance of Genome Resources, Apr 2025]
Rat Ccr5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615429 | View Product |
| AAV Vector & Virus | Long-term expression | VC615429 | View Product |
| Adenovirus | Transient expression | A615429 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615429 | View Product |
| Gene knockout (non-viral) | PG615429 | View Product | |
| Gene knockout (AAV) | VG615429 | View Product | |
| CRISPR Activation | Gene activation | LA615429 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615429 | View Product |
| Gene knockdown (AAV) | VS615429 | View Product | |
| ORF Vector | Template DNA | PC615429 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |