CD19 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CD19-specific vectors and viral particles designed for reliable CD19 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CD19 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CD19 Gene Overview
| Gene Name | CD19 molecule |
|---|---|
| Gene ID | CD19 |
| Aliases | B4, CVID3 |
| NCBI ID | 930 |
| Ensembl ID | ENSG00000177455 |
| Uniprot ID | P15391 |
| Gene Type | Protein-coding |
Gene Summary & Function
This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Human CD19 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115480 | View Product |
| AAV Vector & Virus | Long-term expression | VC115480 | View Product |
| Adenovirus | Transient expression | A115480 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115480 | View Product |
| Gene knockout (AAV) | VG115480 | View Product | |
| Gene knockout (non-viral) | PG115480 | View Product | |
| CRISPR Activation | Gene activation | LA115480 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115480 | View Product |
| Gene knockdown (AAV) | VS115480 | View Product | |
| Gene knockdown (Synthetic) | PS115480 | View Product | |
| ORF Vector | Template DNA | PC115480 | View Product |
Mouse Cd19 Gene Overview
| Gene Name | CD19 antigen |
|---|---|
| Gene ID | Cd19 |
| Aliases | B4, CVID3 |
| NCBI ID | 12478 |
| Ensembl ID | ENSMUSG00000030 |
| Uniprot ID | P25918 |
| Gene Type | Protein-coding |
Gene Summary & Function
Involved in several processes, including B-1 B cell differentiation; positive regulation of release of sequestered calcium ion into cytosol; and regulation of signal transduction. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency 3. Orthologous to human CD19 (CD19 molecule)
Mouse CD19 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415480 | View Product |
| AAV Vector & Virus | Long-term expression | VC415480 | View Product |
| Adenovirus | Transient expression | A415480 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415480 | View Product |
| Gene knockout (AAV) | VG415480 | View Product | |
| Gene knockout (non-viral) | PG415480 | View Product | |
| CRISPR Activation | Gene activation | LA415480 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415480 | View Product |
| Gene knockdown (AAV) | VS415480 | View Product | |
| Gene knockdown (Synthetic) | PS415480 | View Product | |
| ORF Vector | Template DNA | PC415480 | View Product |
Rat Cd19 Gene Overview
| Gene Name | CD19 molecule |
|---|---|
| Gene ID | Cd19 |
| Aliases | B4, CVID3 |
| NCBI ID | 365367 |
| Ensembl ID | ENSRNOG00000018311 |
| Gene Type | Protein-coding |
Gene Summary & Function
Predicted to be involved in several processes, including B cell activation; B cell receptor signaling pathway; and regulation of signal transduction. Predicted to act upstream of or within positive regulation of release of sequestered calcium ion into cytosol. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency 3. Orthologous to human CD19 (CD19 molecule)
Rat CD19 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615480 | View Product |
| AAV Vector & Virus | Long-term expression | VC615480 | View Product |
| Adenovirus | Transient expression | A615480 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615480 | View Product |
| Gene knockout (AAV) | VG615480 | View Product | |
| Gene knockout (non-viral) | PG615480 | View Product | |
| CRISPR Activation | Gene activation | LA615480 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615480 | View Product |
| Gene knockdown (AAV) | VS615480 | View Product | |
| Gene knockdown (Synthetic) | PS615480 | View Product | |
| ORF Vector | Template DNA | PC615480 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |