CD274 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CD274-specific vectors and viral particles designed for reliable CD274 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CD274 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CD274 Gene Overview
| Gene Name | CD274 molecule |
|---|---|
| Gene Symbol | CD274 |
| Synonyms | B7-H,B7H1,PDL1,PD-L1,ADMIO5,hPD-L1,PDCD1L1,PDCD1LG1 |
| NCBI ID | 29126 |
| Ensembl ID | ENSG00000120217 |
| Uniprot ID | Q9NZQ7 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Human CD274 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115516 | View Product |
| AAV Vector & Virus | Long-term expression | VC115516 | View Product |
| Adenovirus | Transient expression | A115516 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115516 | View Product |
| Gene knockout (non-viral) | PG115516 | View Product | |
| Gene knockout (AAV) | VG115516 | View Product | |
| CRISPR Activation | Gene activation | LA115516 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115516 | View Product |
| Gene knockdown (AAV) | VS115516 | View Product | |
| ORF Vector | Template DNA | PC115516 | View Product |
Mouse Cd274 Gene Overview
| Gene Name | CD274 antigen |
|---|---|
| Gene Symbol | Cd274 |
| Synonyms | B7h1,Pdl1,Pdcd1l1,Pdcd1lg1,A530045L16Rik |
| NCBI ID | 60533 |
| Ensembl ID | ENSMUSG00000016496 |
| Uniprot ID | Q9EP73 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]
Mouse Cd274 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415516 | View Product |
| AAV Vector & Virus | Long-term expression | VC415516 | View Product |
| Adenovirus | Transient expression | A415516 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415516 | View Product |
| Gene knockout (non-viral) | PG415516 | View Product | |
| Gene knockout (AAV) | VG415516 | View Product | |
| CRISPR Activation | Gene activation | LA415516 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415516 | View Product |
| Gene knockdown (AAV) | VS415516 | View Product | |
| ORF Vector | Template DNA | PC415516 | View Product |
Rat Cd274 Gene Overview
| Gene Name | CD274 molecule |
|---|---|
| Gene Symbol | Cd274 |
| Synonyms | Pdcd1lg1,RGD1566211 |
| NCBI ID | 499342 |
| Ensembl ID | ENSRNOG00000016112 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable receptor ligand activity and transcription coactivator activity. Involved in positive regulation of T cell proliferation and positive regulation of cell migration. Located in cell surface. Biomarker of periodontitis and pre-eclampsia. Orthologous to human CD274 (CD274 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Rat Cd274 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615516 | View Product |
| AAV Vector & Virus | Long-term expression | VC615516 | View Product |
| Adenovirus | Transient expression | A615516 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615516 | View Product |
| Gene knockout (non-viral) | PG615516 | View Product | |
| Gene knockout (AAV) | VG615516 | View Product | |
| CRISPR Activation | Gene activation | LA615516 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615516 | View Product |
| Gene knockdown (AAV) | VS615516 | View Product | |
| ORF Vector | Template DNA | PC615516 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |