CD4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CD4-specific vectors and viral particles designed for reliable CD4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CD4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CD4 Gene Overview
| Gene Name | CD4 molecule |
|---|---|
| Gene Symbol | CD4 |
| Synonyms | T4,IMD79,Leu-3,OKT4D,CD4mut |
| NCBI ID | 920 |
| Ensembl ID | ENSG00000010610 |
| Uniprot ID | P01730 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]
Human CD4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115542 | View Product |
| AAV Vector & Virus | Long-term expression | VC115542 | View Product |
| Adenovirus | Transient expression | A115542 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115542 | View Product |
| Gene knockout (non-viral) | PG115542 | View Product | |
| Gene knockout (AAV) | VG115542 | View Product | |
| CRISPR Activation | Gene activation | LA115542 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115542 | View Product |
| Gene knockdown (AAV) | VS115542 | View Product | |
| ORF Vector | Template DNA | PC115542 | View Product |
Mouse Cd4 Gene Overview
| Gene Name | CD4 antigen |
|---|---|
| Gene Symbol | Cd4 |
| Synonyms | L3T4,Ly-4 |
| NCBI ID | 12504 |
| Ensembl ID | ENSMUSG00000023274 |
| Uniprot ID | P06332 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in cell surface receptor signaling pathway and helper T cell enhancement of adaptive immune response. Acts upstream of or within several processes, including defense response to Gram-negative bacterium; positive regulation of calcium-mediated signaling; and positive regulation of peptidyl-tyrosine phosphorylation. Located in endoplasmic reticulum; external side of plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study glycogen storage disease II. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Cd4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415542 | View Product |
| AAV Vector & Virus | Long-term expression | VC415542 | View Product |
| Adenovirus | Transient expression | A415542 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415542 | View Product |
| Gene knockout (non-viral) | PG415542 | View Product | |
| Gene knockout (AAV) | VG415542 | View Product | |
| CRISPR Activation | Gene activation | LA415542 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415542 | View Product |
| Gene knockdown (AAV) | VS415542 | View Product | |
| ORF Vector | Template DNA | PC415542 | View Product |
Rat Cd4 Gene Overview
| Gene Name | Cd4 molecule |
|---|---|
| Gene Symbol | Cd4 |
| Synonyms | p55,W3/25 |
| NCBI ID | 24932 |
| Ensembl ID | ENSRNOG00000071219 |
| Uniprot ID | P05540 |
| Gene Type | Protein coding |
Gene Summary
Enables immunoglobulin binding activity; protein tyrosine kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ionomycin; positive regulation of calcium ion transport into cytosol; and response to vitamin D. Located in external side of plasma membrane. Used to study septic arthritis and sialadenitis. Biomarker of amphetamine abuse. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Rat Cd4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615542 | View Product |
| AAV Vector & Virus | Long-term expression | VC615542 | View Product |
| Adenovirus | Transient expression | A615542 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615542 | View Product |
| Gene knockout (non-viral) | PG615542 | View Product | |
| Gene knockout (AAV) | VG615542 | View Product | |
| CRISPR Activation | Gene activation | LA615542 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615542 | View Product |
| Gene knockdown (AAV) | VS615542 | View Product | |
| ORF Vector | Template DNA | PC615542 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |