CDH1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CDH1-specific vectors and viral particles designed for reliable CDH1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CDH1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CDH1 Gene Overview
| Gene Name | cadherin 1 |
|---|---|
| Gene Symbol | CDH1 |
| Synonyms | UVO,CDHE,ECAD,LCAM,Arc-1,BCDS1,CD324 |
| NCBI ID | 999 |
| Ensembl ID | ENSG00000039068 |
| Uniprot ID | P12830 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Human CDH1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115647 | View Product |
| AAV Vector & Virus | Long-term expression | VC115647 | View Product |
| Adenovirus | Transient expression | A115647 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115647 | View Product |
| Gene knockout (non-viral) | PG115647 | View Product | |
| Gene knockout (AAV) | VG115647 | View Product | |
| CRISPR Activation | Gene activation | LA115647 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115647 | View Product |
| Gene knockdown (AAV) | VS115647 | View Product | |
| ORF Vector | Template DNA | PC115647 | View Product |
Mouse Cdh1 Gene Overview
| Gene Name | cadherin 1 |
|---|---|
| Gene Symbol | Cdh1 |
| Synonyms | Um,UVO,Ecad,ARC-1,E-cad,L-CAM |
| NCBI ID | 12550 |
| Ensembl ID | ENSMUSG00000000303 |
| Uniprot ID | P09803 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]
Mouse Cdh1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415647 | View Product |
| AAV Vector & Virus | Long-term expression | VC415647 | View Product |
| Adenovirus | Transient expression | A415647 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415647 | View Product |
| Gene knockout (non-viral) | PG415647 | View Product | |
| Gene knockout (AAV) | VG415647 | View Product | |
| CRISPR Activation | Gene activation | LA415647 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415647 | View Product |
| Gene knockdown (AAV) | VS415647 | View Product | |
| ORF Vector | Template DNA | PC415647 | View Product |
Rat Cdh1 Gene Overview
| Gene Name | cadherin 1 |
|---|---|
| Gene Symbol | Cdh1 |
| Synonyms | |
| NCBI ID | 83502 |
| Ensembl ID | ENSRNOG00000020151 |
| Uniprot ID | Q9R0T4 |
| Gene Type | Protein coding |
Gene Summary
Enables beta-catenin binding activity and protein tyrosine kinase binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to Gram-positive bacterium. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Cdh1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615647 | View Product |
| AAV Vector & Virus | Long-term expression | VC615647 | View Product |
| Adenovirus | Transient expression | A615647 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615647 | View Product |
| Gene knockout (non-viral) | PG615647 | View Product | |
| Gene knockout (AAV) | VG615647 | View Product | |
| CRISPR Activation | Gene activation | LA615647 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615647 | View Product |
| Gene knockdown (AAV) | VS615647 | View Product | |
| ORF Vector | Template DNA | PC615647 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |