CDK4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CDK4-specific vectors and viral particles designed for reliable CDK4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CDK4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CDK4 Gene Overview
| Gene Name | cyclin dependent kinase 4 |
|---|---|
| Gene Symbol | CDK4 |
| Synonyms | CMM3,MCPH31,PSK-J3 |
| NCBI ID | 1019 |
| Ensembl ID | ENSG00000135446 |
| Uniprot ID | P11802 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Human CDK4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115704 | View Product |
| AAV Vector & Virus | Long-term expression | VC115704 | View Product |
| Adenovirus | Transient expression | A115704 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115704 | View Product |
| Gene knockout (non-viral) | PG115704 | View Product | |
| Gene knockout (AAV) | VG115704 | View Product | |
| CRISPR Activation | Gene activation | LA115704 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115704 | View Product |
| Gene knockdown (AAV) | VS115704 | View Product | |
| ORF Vector | Template DNA | PC115704 | View Product |
Mouse Cdk4 Gene Overview
| Gene Name | cyclin dependent kinase 4 |
|---|---|
| Gene Symbol | Cdk4 |
| Synonyms | Crk3 |
| NCBI ID | 12567 |
| Ensembl ID | ENSMUSG00000006728 |
| Uniprot ID | P30285 |
| Gene Type | Protein coding |
Gene Summary
Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to ionomycin; cellular response to lipopolysaccharide; and cellular response to phorbol 13-acetate 12-myristate. Located in bicellular tight junction and nucleus. Part of cyclin D1-CDK4 complex; cyclin D2-CDK4 complex; and transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; nervous system; sensory organ; and urinary system. Used to study skin melanoma and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Cdk4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415704 | View Product |
| AAV Vector & Virus | Long-term expression | VC415704 | View Product |
| Adenovirus | Transient expression | A415704 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415704 | View Product |
| Gene knockout (non-viral) | PG415704 | View Product | |
| Gene knockout (AAV) | VG415704 | View Product | |
| CRISPR Activation | Gene activation | LA415704 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415704 | View Product |
| Gene knockdown (AAV) | VS415704 | View Product | |
| ORF Vector | Template DNA | PC415704 | View Product |
Rat Cdk4 Gene Overview
| Gene Name | cyclin-dependent kinase 4 |
|---|---|
| Gene Symbol | Cdk4 |
| Synonyms | |
| NCBI ID | 94201 |
| Ensembl ID | |
| Uniprot ID | P35426 |
| Gene Type | Protein coding |
Gene Summary
Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including cellular response to polyamine macromolecule; positive regulation of cell size; and response to hyperoxia. Located in nucleus and perinuclear region of cytoplasm. Biomarker of hepatocellular carcinoma; pancreatic cancer; prostatic hypertrophy; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Rat Cdk4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615704 | View Product |
| AAV Vector & Virus | Long-term expression | VC615704 | View Product |
| Adenovirus | Transient expression | A615704 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615704 | View Product |
| Gene knockout (non-viral) | PG615704 | View Product | |
| Gene knockout (AAV) | VG615704 | View Product | |
| CRISPR Activation | Gene activation | LA615704 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615704 | View Product |
| Gene knockdown (AAV) | VS615704 | View Product | |
| ORF Vector | Template DNA | PC615704 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |