CDKN2A Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CDKN2A-specific vectors and viral particles designed for reliable CDKN2A overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CDKN2A CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CDKN2A Gene Overview
| Gene Name | cyclin dependent kinase inhibitor 2A |
|---|---|
| Gene Symbol | CDKN2A |
| Synonyms | ARF,MLM,P14,P16,P19,CAI2,CMM2,INK4,MTS1,TP16,CDK4I,CDKN2,INK4A,MTS-1,P14ARF,P19ARF,P16INK4,P16INK4A,P16-INK4A |
| NCBI ID | 1029 |
| Ensembl ID | ENSG00000147889 |
| Uniprot ID | P42771,Q8N726 |
| Gene Type | Protein coding |
Gene Summary
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
Human CDKN2A Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115729 | View Product |
| AAV Vector & Virus | Long-term expression | VC115729 | View Product |
| Adenovirus | Transient expression | A115729 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115729 | View Product |
| Gene knockout (non-viral) | PG115729 | View Product | |
| Gene knockout (AAV) | VG115729 | View Product | |
| CRISPR Activation | Gene activation | LA115729 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115729 | View Product |
| Gene knockdown (AAV) | VS115729 | View Product | |
| ORF Vector | Template DNA | PC115729 | View Product |
Mouse Cdkn2a Gene Overview
| Gene Name | cyclin dependent kinase inhibitor 2A |
|---|---|
| Gene Symbol | Cdkn2a |
| Synonyms | Arf,p16,MTS1,Pctr1,p19ARF,p16INK4a,p19 |
| NCBI ID | 12578 |
| Ensembl ID | ENSMUSG00000044303 |
| Uniprot ID | P51480,Q64364 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and enzyme inhibitor activity. Involved in several processes, including cellular response to gamma radiation; negative regulation of lymphocyte proliferation; and positive regulation of apoptotic process. Acts upstream of or within several processes, including keratinocyte proliferation; negative regulation of mammary gland epithelial cell proliferation; and negative regulation of protein metabolic process. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; immune system; and umbilical artery. Used to study high grade glioma; malignant peripheral nerve sheath tumor; melanoma (multiple); and pancreatic carcinoma (multiple). Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Cdkn2a Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415729 | View Product |
| Stable overexpression | LC515729 | View Product | |
| AAV Vector & Virus | Long-term expression | VC415729 | View Product |
| Long-term expression | VC515729 | View Product | |
| Adenovirus | Transient expression | A415729 | View Product |
| Transient expression | A515729 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415729 | View Product |
| Gene knockout (non-viral) | PG415729 | View Product | |
| Gene knockout (AAV) | VG415729 | View Product | |
| CRISPR Activation | Gene activation | LA415729 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415729 | View Product |
| Gene knockdown (AAV) | VS415729 | View Product | |
| ORF Vector | Template DNA | PC415729 | View Product |
| Template DNA | PC515729 | View Product |
Rat Cdkn2a Gene Overview
| Gene Name | cyclin-dependent kinase inhibitor 2A |
|---|---|
| Gene Symbol | Cdkn2a |
| Synonyms | Arf,p16,MTS1,INK4A,p19ARF,p16Cdkn2a |
| NCBI ID | 25163 |
| Ensembl ID | ENSRNOG00000059837 |
| Uniprot ID | Q8QZZ9,Q9R0Z3 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and enzyme inhibitor activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of hepatocyte proliferation; and nervous system development. Predicted to be located in mitochondrion; nuclear lumen; and senescence-associated heterochromatin focus. Predicted to be part of protein-containing complex. Used to study carcinoma (multiple); endometrial cancer; pre-malignant neoplasm; rhabdomyosarcoma; and sarcomatoid mesothelioma. Biomarker of hepatocellular carcinoma; hypertension; obesity; and osteoarthritis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and pancreatic cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Jul 2025]
Rat Cdkn2a Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615729 | View Product |
| AAV Vector & Virus | Long-term expression | VC615729 | View Product |
| Adenovirus | Transient expression | A615729 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615729 | View Product |
| Gene knockout (non-viral) | PG615729 | View Product | |
| Gene knockout (AAV) | VG615729 | View Product | |
| CRISPR Activation | Gene activation | LA615729 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615729 | View Product |
| Gene knockdown (AAV) | VS615729 | View Product | |
| ORF Vector | Template DNA | PC615729 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |