CFTR Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CFTR-specific vectors and viral particles designed for reliable CFTR overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CFTR CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CFTR Gene Overview
| Gene Name | CF transmembrane conductance regulator |
|---|---|
| Gene Symbol | CFTR |
| Synonyms | CF,MRP7,ABC35,ABCC7,CFTR/MRP,TNR-CFTR,dJ760C5.1 |
| NCBI ID | 1080 |
| Ensembl ID | ENSG00000001626 |
| Uniprot ID | P13569 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]
Human CFTR Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC115994 | View Product |
| Adenovirus | Transient expression | A115994 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG115994 | View Product |
| Gene knockout (non-viral) | PG115994 | View Product | |
| Gene knockout (AAV) | VG115994 | View Product | |
| CRISPR Activation | Gene activation | LA115994 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS115994 | View Product |
| Gene knockdown (AAV) | VS115994 | View Product | |
| ORF Vector | Template DNA | PC115994 | View Product |
Mouse Cftr Gene Overview
| Gene Name | cystic fibrosis transmembrane conductance regulator |
|---|---|
| Gene Symbol | Cftr |
| Synonyms | Abcc7 |
| NCBI ID | 12638 |
| Ensembl ID | ENSMUSG00000041301 |
| Uniprot ID | P26361 |
| Gene Type | Protein coding |
Gene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This gene encodes the cystic fibrosis transmembrane regulator and a chloride channel that controls the regulation of other transport pathways. Mutations in this gene have been associated with autosomal recessive disorders such as cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternative splicing of exons 4, 5, and 11 have been observed, but full-length transcripts have not yet been fully described. [provided by RefSeq, Jul 2008]
Mouse Cftr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC415994 | View Product |
| Adenovirus | Transient expression | A415994 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG415994 | View Product |
| Gene knockout (non-viral) | PG415994 | View Product | |
| Gene knockout (AAV) | VG415994 | View Product | |
| CRISPR Activation | Gene activation | LA415994 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS415994 | View Product |
| Gene knockdown (AAV) | VS415994 | View Product | |
| ORF Vector | Template DNA | PC415994 | View Product |
Rat Cftr Gene Overview
| Gene Name | CF transmembrane conductance regulator |
|---|---|
| Gene Symbol | Cftr |
| Synonyms | RGD1561193 |
| NCBI ID | 24255 |
| Ensembl ID | ENSRNOG00000055103 |
| Uniprot ID | P34158 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; ATP hydrolysis activity; and PDZ domain binding activity. Involved in several processes, including bicarbonate transport; cellular response to anoxia; and regulation of cell development. Located in several cellular components, including basolateral plasma membrane; early endosome; and microvillus. Used to study congenital bilateral absence of vas deferens; cystic fibrosis; dental enamel hypoplasia; duodenal ulcer; and gastric ulcer. Biomarker of autosomal recessive polycystic kidney disease; cholestasis; and salpingitis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator). [provided by Alliance of Genome Resources, Jul 2025]
Rat Cftr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC615994 | View Product |
| Adenovirus | Transient expression | A615994 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG615994 | View Product |
| Gene knockout (non-viral) | PG615994 | View Product | |
| Gene knockout (AAV) | VG615994 | View Product | |
| CRISPR Activation | Gene activation | LA615994 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS615994 | View Product |
| Gene knockdown (AAV) | VS615994 | View Product | |
| ORF Vector | Template DNA | PC615994 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |