CGAS Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CGAS-specific vectors and viral particles designed for reliable CGAS overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CGAS CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CGAS Gene Overview
| Gene Name | cyclic GMP-AMP synthase |
|---|---|
| Gene Symbol | CGAS |
| Synonyms | D4,MB21D1,h-cGAS,C6orf150 |
| NCBI ID | 115004 |
| Ensembl ID | ENSG00000164430 |
| Uniprot ID | Q8N884 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; molecular condensate scaffold activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including intracellular signal transduction; paracrine signaling; and regulation of defense response. Located in nuclear body; plasma membrane; and site of double-strand break. Is active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Human CGAS Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC128157 | View Product |
| AAV Vector & Virus | Long-term expression | VC128157 | View Product |
| Adenovirus | Transient expression | A128157 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG128157 | View Product |
| Gene knockout (non-viral) | PG128157 | View Product | |
| Gene knockout (AAV) | VG128157 | View Product | |
| CRISPR Activation | Gene activation | LA128157 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS128157 | View Product |
| Gene knockdown (AAV) | VS128157 | View Product | |
| ORF Vector | Template DNA | PC128157 | View Product |
Mouse Cgas Gene Overview
| Gene Name | cyclic GMP-AMP synthase |
|---|---|
| Gene Symbol | Cgas |
| Synonyms | Mb21d1,E330016A19Rik |
| NCBI ID | 214763 |
| Ensembl ID | ENSMUSG00000032344 |
| Uniprot ID | Q8C6L5 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Mouse Cgas Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Rat Cgas Gene Overview
| Gene Name | cyclic GMP-AMP synthase |
|---|---|
| Gene Symbol | Cgas |
| Synonyms | Mb21d1 |
| NCBI ID | 682147 |
| Ensembl ID | ENSRNOG00000046191 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including 2',3'-cyclic GMP-AMP synthase activity; molecular condensate scaffold activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including cellular response to exogenous dsRNA; intracellular signal transduction; and regulation of defense response. Predicted to act upstream of or within several processes, including determination of adult lifespan; regulation of T cell activation; and regulation of gene expression. Predicted to be located in nuclear body and plasma membrane. Predicted to be active in cytosol; nucleus; and site of double-strand break. Orthologous to human CGAS (cyclic GMP-AMP synthase). [provided by Alliance of Genome Resources, Apr 2025]
Rat Cgas Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |