CTCF Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CTCF-specific vectors and viral particles designed for reliable CTCF overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CTCF CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CTCF Gene Overview
| Gene Name | CCCTC-binding factor |
|---|---|
| Gene Symbol | CTCF |
| Synonyms | MRD21,FAP108,CFAP108 |
| NCBI ID | 10664 |
| Ensembl ID | ENSG00000102974 |
| Uniprot ID | P49711 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Human CTCF Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC117044 | View Product |
| AAV Vector & Virus | Long-term expression | VC117044 | View Product |
| Adenovirus | Transient expression | A117044 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG117044 | View Product |
| Gene knockout (non-viral) | PG117044 | View Product | |
| Gene knockout (AAV) | VG117044 | View Product | |
| CRISPR Activation | Gene activation | LA117044 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS117044 | View Product |
| Gene knockdown (AAV) | VS117044 | View Product | |
| ORF Vector | Template DNA | PC117044 | View Product |
Mouse Ctcf Gene Overview
| Gene Name | CCCTC-binding factor |
|---|---|
| Gene Symbol | Ctcf |
| Synonyms | |
| NCBI ID | 13018 |
| Ensembl ID | ENSMUSG00000005698 |
| Uniprot ID | Q61164 |
| Gene Type | Protein coding |
Gene Summary
Enables chromatin binding activity and cis-regulatory region sequence-specific DNA binding activity. Involved in chromatin looping; negative regulation of gene expression; and positive regulation of gene expression. Acts upstream of or within several processes, including cardiac muscle cell development; epigenetic regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 21; basal cell carcinoma; female breast cancer; skin melanoma; and skin squamous cell carcinoma. Orthologous to human CTCF (CCCTC-binding factor). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ctcf Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC417044 | View Product |
| AAV Vector & Virus | Long-term expression | VC417044 | View Product |
| Adenovirus | Transient expression | A417044 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG417044 | View Product |
| Gene knockout (non-viral) | PG417044 | View Product | |
| Gene knockout (AAV) | VG417044 | View Product | |
| CRISPR Activation | Gene activation | LA417044 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS417044 | View Product |
| Gene knockdown (AAV) | VS417044 | View Product | |
| ORF Vector | Template DNA | PC417044 | View Product |
Rat Ctcf Gene Overview
| Gene Name | CCCTC-binding factor |
|---|---|
| Gene Symbol | Ctcf |
| Synonyms | |
| NCBI ID | 83726 |
| Ensembl ID | ENSRNOG00000017674 |
| Uniprot ID | Q9R1D1 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor binding activity. Involved in positive regulation of miRNA transcription. Located in dense fibrillar component and granular component. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 21; basal cell carcinoma; female breast cancer; skin melanoma; and skin squamous cell carcinoma. Orthologous to human CTCF (CCCTC-binding factor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ctcf Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC617044 | View Product |
| AAV Vector & Virus | Long-term expression | VC617044 | View Product |
| Adenovirus | Transient expression | A617044 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG617044 | View Product |
| Gene knockout (non-viral) | PG617044 | View Product | |
| Gene knockout (AAV) | VG617044 | View Product | |
| CRISPR Activation | Gene activation | LA617044 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS617044 | View Product |
| Gene knockdown (AAV) | VS617044 | View Product | |
| ORF Vector | Template DNA | PC617044 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |