CTLA4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CTLA4-specific vectors and viral particles designed for reliable CTLA4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CTLA4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CTLA4 Gene Overview
| Gene Name | cytotoxic T-lymphocyte associated protein 4 |
|---|---|
| Gene Symbol | CTLA4 |
| Synonyms | CD,GSE,GRD4,ALPS5,CD152,CTLA-4,IDDM12,CELIAC3 |
| NCBI ID | 1493 |
| Ensembl ID | ENSG00000163599 |
| Uniprot ID | P16410 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Human CTLA4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC117068 | View Product |
| AAV Vector & Virus | Long-term expression | VC117068 | View Product |
| Adenovirus | Transient expression | A117068 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG117068 | View Product |
| Gene knockout (non-viral) | PG117068 | View Product | |
| Gene knockout (AAV) | VG117068 | View Product | |
| CRISPR Activation | Gene activation | LA117068 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS117068 | View Product |
| Gene knockdown (AAV) | VS117068 | View Product | |
| ORF Vector | Template DNA | PC117068 | View Product |
Mouse Ctla4 Gene Overview
| Gene Name | cytotoxic T-lymphocyte-associated protein 4 |
|---|---|
| Gene Symbol | Ctla4 |
| Synonyms | Cd152,Ly-56,Ctla-4 |
| NCBI ID | 12477 |
| Ensembl ID | ENSMUSG00000026011 |
| Uniprot ID | P09793 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
Mouse Ctla4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC417068 | View Product |
| AAV Vector & Virus | Long-term expression | VC417068 | View Product |
| Adenovirus | Transient expression | A417068 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG417068 | View Product |
| Gene knockout (non-viral) | PG417068 | View Product | |
| Gene knockout (AAV) | VG417068 | View Product | |
| CRISPR Activation | Gene activation | LA417068 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS417068 | View Product |
| Gene knockdown (AAV) | VS417068 | View Product | |
| ORF Vector | Template DNA | PC417068 | View Product |
Rat Ctla4 Gene Overview
| Gene Name | cytotoxic T-lymphocyte-associated protein 4 |
|---|---|
| Gene Symbol | Ctla4 |
| Synonyms | Cd152,CTLA-4,sCTLA4 |
| NCBI ID | 63835 |
| Ensembl ID | ENSRNOG00000054129 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Involved in negative regulation of T cell proliferation. Predicted to be located in several cellular components, including Golgi apparatus; clathrin-coated endocytic vesicle; and perinuclear region of cytoplasm. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in external side of plasma membrane. Used to study myocarditis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); graft-versus-host disease; hematologic cancer (multiple); kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ctla4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC617068 | View Product |
| AAV Vector & Virus | Long-term expression | VC617068 | View Product |
| Adenovirus | Transient expression | A617068 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG617068 | View Product |
| Gene knockout (non-viral) | PG617068 | View Product | |
| Gene knockout (AAV) | VG617068 | View Product | |
| CRISPR Activation | Gene activation | LA617068 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS617068 | View Product |
| Gene knockdown (AAV) | VS617068 | View Product | |
| ORF Vector | Template DNA | PC617068 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |