CXCR2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use CXCR2-specific vectors and viral particles designed for reliable CXCR2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including CXCR2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human CXCR2 Gene Overview
| Gene Name | C-X-C motif chemokine receptor 2 |
|---|---|
| Gene Symbol | CXCR2 |
| Synonyms | CD182,IL8R2,IL8RA,IL8RB,SCN13,CMKAR2,WHIMS2,CDw128b |
| NCBI ID | 3579 |
| Ensembl ID | ENSG00000180871 |
| Uniprot ID | P25025 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Human CXCR2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC117181 | View Product |
| AAV Vector & Virus | Long-term expression | VC117181 | View Product |
| Adenovirus | Transient expression | A117181 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG117181 | View Product |
| Gene knockout (Lentiviral) | LG124909 | View Product | |
| Gene knockout (non-viral) | PG117181 | View Product | |
| Gene knockout (non-viral) | PG124909 | View Product | |
| Gene knockout (AAV) | VG117181 | View Product | |
| Gene knockout (AAV) | VG124909 | View Product | |
| CRISPR Activation | Gene activation | LA117181 | View Product |
| Gene activation | LA124909 | View Product | |
| siRNA Tools | Gene knockdown (Lentiviral) | LS117181 | View Product |
| Gene knockdown (Lentiviral) | LS124909 | View Product | |
| Gene knockdown (AAV) | VS117181 | View Product | |
| Gene knockdown (AAV) | VS124909 | View Product | |
| ORF Vector | Template DNA | PC124909 | View Product |
Mouse Cxcr2 Gene Overview
| Gene Name | C-X-C motif chemokine receptor 2 |
|---|---|
| Gene Symbol | Cxcr2 |
| Synonyms | CD128,IL8RA,Il8rb,CDw128,Cmkar2,Gpcr16,IL-8Rh,IL-8rb,mIL-8RH |
| NCBI ID | 12765 |
| Ensembl ID | ENSMUSG00000026180 |
| Uniprot ID | P35343 |
| Gene Type | Protein coding |
Gene Summary
Enables chemokine receptor activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; epithelium; and heart. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; WHIM syndrome 2; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Orthologous to human CXCR2 (C-X-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Cxcr2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC417181 | View Product |
| AAV Vector & Virus | Long-term expression | VC417181 | View Product |
| Adenovirus | Transient expression | A417181 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG417181 | View Product |
| Gene knockout (non-viral) | PG417181 | View Product | |
| Gene knockout (AAV) | VG417181 | View Product | |
| CRISPR Activation | Gene activation | LA417181 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS417181 | View Product |
| Gene knockdown (AAV) | VS417181 | View Product | |
| ORF Vector | Template DNA | PC417181 | View Product |
Rat Cxcr2 Gene Overview
| Gene Name | C-X-C motif chemokine receptor 2 |
|---|---|
| Gene Symbol | Cxcr2 |
| Synonyms | Il8rb,Cmkar2 |
| NCBI ID | 29385 |
| Ensembl ID | ENSRNOG00000063618 |
| Uniprot ID | P35407 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable chemokine binding activity and chemokine receptor activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of neutrophil chemotaxis; and regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Used to study colitis; demyelinating disease; and nephritis. Biomarker of periapical periodontitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; WHIM syndrome 2; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Orthologous to human CXCR2 (C-X-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Cxcr2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC617181 | View Product |
| AAV Vector & Virus | Long-term expression | VC617181 | View Product |
| Adenovirus | Transient expression | A617181 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG617181 | View Product |
| Gene knockout (non-viral) | PG617181 | View Product | |
| Gene knockout (AAV) | VG617181 | View Product | |
| CRISPR Activation | Gene activation | LA617181 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS617181 | View Product |
| Gene knockdown (AAV) | VS617181 | View Product | |
| ORF Vector | Template DNA | PC617181 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |