EGFR Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use EGFR-specific vectors and viral particles designed for reliable EGFR overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including EGFR CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human EGFR Gene Overview
| Gene Name | epidermal growth factor receptor |
|---|---|
| Gene Symbol | EGFR |
| Synonyms | ERBB,ERRP,HER1,mENA,ERBB1,NNCIS,PIG61,NISBD2 |
| NCBI ID | 1956 |
| Ensembl ID | ENSG00000146648 |
| Uniprot ID | P00533 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]
Human EGFR Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC119039 | View Product |
| Adenovirus | Transient expression | A119039 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG119039 | View Product |
| Gene knockout (non-viral) | PG119039 | View Product | |
| Gene knockout (AAV) | VG119039 | View Product | |
| CRISPR Activation | Gene activation | LA119039 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS119039 | View Product |
| Gene knockdown (AAV) | VS119039 | View Product | |
| ORF Vector | Template DNA | PC119039 | View Product |
Mouse Egfr Gene Overview
| Gene Name | epidermal growth factor receptor |
|---|---|
| Gene Symbol | Egfr |
| Synonyms | Wa5,wa2,Erbb,Errp,wa-2,Errb1,9030024J15Rik |
| NCBI ID | 13649 |
| Ensembl ID | ENSMUSG00000020122 |
| Uniprot ID | Q01279 |
| Gene Type | Protein coding |
Gene Summary
Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in ERBB2-EGFR signaling pathway; cellular response to amino acid stimulus; and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including eyelid development in camera-type eye; protein modification process; and regulation of epidermal growth factor receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and sensory organ. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Egfr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC419039 | View Product |
| Stable overexpression | LC519039 | View Product | |
| AAV Vector & Virus | Long-term expression | VC419039 | View Product |
| Adenovirus | Transient expression | A419039 | View Product |
| Transient expression | A519039 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG419039 | View Product |
| Gene knockout (non-viral) | PG419039 | View Product | |
| Gene knockout (AAV) | VG419039 | View Product | |
| CRISPR Activation | Gene activation | LA419039 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS419039 | View Product |
| Gene knockdown (AAV) | VS419039 | View Product | |
| ORF Vector | Template DNA | PC419039 | View Product |
| Template DNA | PC519039 | View Product |
Rat Egfr Gene Overview
| Gene Name | epidermal growth factor receptor |
|---|---|
| Gene Symbol | Egfr |
| Synonyms | Errp,ERBB1,ErbB-1 |
| NCBI ID | 24329 |
| Ensembl ID | ENSRNOG00000004332 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including calmodulin binding activity; enzyme binding activity; and epidermal growth factor binding activity. Involved in several processes, including blood vessel diameter maintenance; positive regulation of cell communication; and protein phosphorylation. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Is active in glutamatergic synapse and synaptic membrane. Used to study bronchiolo-alveolar adenocarcinoma; dilated cardiomyopathy; and high grade glioma. Biomarker of several diseases, including Parkinsonism; lung disease (multiple); median neuropathy; nicotine dependence; and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Egfr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC619039 | View Product |
| Adenovirus | Transient expression | A619039 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG619039 | View Product |
| Gene knockout (non-viral) | PG619039 | View Product | |
| Gene knockout (AAV) | VG619039 | View Product | |
| CRISPR Activation | Gene activation | LA619039 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS619039 | View Product |
| Gene knockdown (AAV) | VS619039 | View Product | |
| ORF Vector | Template DNA | PC619039 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |