EIF2AK2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use EIF2AK2-specific vectors and viral particles designed for reliable EIF2AK2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including EIF2AK2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human EIF2AK2 Gene Overview
| Gene Name | eukaryotic translation initiation factor 2 alpha kinase 2 |
|---|---|
| Gene Symbol | EIF2AK2 |
| Synonyms | PKR,PRKR,PPP1R83 |
| NCBI ID | 5610 |
| Ensembl ID | ENSG00000055332 |
| Uniprot ID | P19525 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]
Human EIF2AK2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC119075 | View Product |
| AAV Vector & Virus | Long-term expression | VC119075 | View Product |
| Adenovirus | Transient expression | A119075 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG119075 | View Product |
| Gene knockout (non-viral) | PG119075 | View Product | |
| Gene knockout (AAV) | VG119075 | View Product | |
| CRISPR Activation | Gene activation | LA119075 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS119075 | View Product |
| Gene knockdown (AAV) | VS119075 | View Product | |
| ORF Vector | Template DNA | PC119075 | View Product |
Mouse Eif2ak2 Gene Overview
| Gene Name | eukaryotic translation initiation factor 2-alpha kinase 2 |
|---|---|
| Gene Symbol | Eif2ak2 |
| Synonyms | Pkr,Tik,Prkr,2310047A08Rik,4732414G15Rik |
| NCBI ID | 19106 |
| Ensembl ID | ENSMUSG00000024079 |
| Uniprot ID | Q03963 |
| Gene Type | Protein coding |
Gene Summary
Enables double-stranded RNA binding activity and protein kinase activity. Involved in several processes, including negative regulation of viral genome replication; regulation of hematopoietic stem cell differentiation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including endoplasmic reticulum unfolded protein response; protein phosphorylation; and translation. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; genitourinary system; mandible condylar process; sensory organ; and skeletal musculature. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; dystonia 33; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Eif2ak2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC419075 | View Product |
| AAV Vector & Virus | Long-term expression | VC419075 | View Product |
| Adenovirus | Transient expression | A419075 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG419075 | View Product |
| Gene knockout (non-viral) | PG419075 | View Product | |
| Gene knockout (AAV) | VG419075 | View Product | |
| CRISPR Activation | Gene activation | LA419075 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS419075 | View Product |
| Gene knockdown (AAV) | VS419075 | View Product | |
| ORF Vector | Template DNA | PC419075 | View Product |
Rat Eif2ak2 Gene Overview
| Gene Name | eukaryotic translation initiation factor 2-alpha kinase 2 |
|---|---|
| Gene Symbol | Eif2ak2 |
| Synonyms | Pkr,Prkr |
| NCBI ID | 54287 |
| Ensembl ID | ENSRNOG00000048315 |
| Uniprot ID | Q63184 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable double-stranded RNA binding activity; eukaryotic translation initiation factor 2alpha kinase activity; and identical protein binding activity. Involved in several processes, including response to exogenous dsRNA; response to lipopolysaccharide; and response to vitamin E. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; dystonia 33; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Eif2ak2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC619075 | View Product |
| AAV Vector & Virus | Long-term expression | VC619075 | View Product |
| Adenovirus | Transient expression | A619075 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG619075 | View Product |
| Gene knockout (non-viral) | PG619075 | View Product | |
| Gene knockout (AAV) | VG619075 | View Product | |
| CRISPR Activation | Gene activation | LA619075 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS619075 | View Product |
| Gene knockdown (AAV) | VS619075 | View Product | |
| ORF Vector | Template DNA | PC619075 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |