ERBB2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ERBB2-specific vectors and viral particles designed for reliable ERBB2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ERBB2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ERBB2 Gene Overview
| Gene Name | erb-b2 receptor tyrosine kinase 2 |
|---|---|
| Gene Symbol | ERBB2 |
| Synonyms | NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-2,HER-2/neu,p185(erbB2) |
| NCBI ID | 2064 |
| Ensembl ID | ENSG00000141736 |
| Uniprot ID | P04626 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Human ERBB2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC119398 | View Product |
| Adenovirus | Transient expression | A119398 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG119398 | View Product |
| Gene knockout (non-viral) | PG119398 | View Product | |
| Gene knockout (AAV) | VG119398 | View Product | |
| CRISPR Activation | Gene activation | LA119398 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS119398 | View Product |
| Gene knockdown (AAV) | VS119398 | View Product | |
| ORF Vector | Template DNA | PC119398 | View Product |
Mouse Erbb2 Gene Overview
| Gene Name | erb-b2 receptor tyrosine kinase 2 |
|---|---|
| Gene Symbol | Erbb2 |
| Synonyms | Neu,HER2,HER-2,c-neu,Erbb-2,c-erbB2,l11Jus8,mKIAA3023 |
| NCBI ID | 13866 |
| Ensembl ID | ENSMUSG00000062312 |
| Uniprot ID | P70424 |
| Gene Type | Protein coding |
Gene Summary
Enables coreceptor activity and protein tyrosine kinase activity. Involved in several processes, including ERBB2 signaling pathway; nervous system development; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Part of semaphorin receptor complex. Is active in neuromuscular junction and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including lung cancer (multiple); mammary Paget's disease; reproductive organ cancer (multiple); stomach cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Erbb2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC419398 | View Product |
| Adenovirus | Transient expression | A419398 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG419398 | View Product |
| Gene knockout (non-viral) | PG419398 | View Product | |
| Gene knockout (AAV) | VG419398 | View Product | |
| CRISPR Activation | Gene activation | LA419398 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS419398 | View Product |
| Gene knockdown (AAV) | VS419398 | View Product | |
| ORF Vector | Template DNA | PC419398 | View Product |
Rat Erbb2 Gene Overview
| Gene Name | erb-b2 receptor tyrosine kinase 2 |
|---|---|
| Gene Symbol | Erbb2 |
| Synonyms | neu,HER2/neu |
| NCBI ID | 24337 |
| Ensembl ID | ENSRNOG00000006450 |
| Uniprot ID | P06494 |
| Gene Type | Protein coding |
Gene Summary
Enables Hsp90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including ERBB2-ERBB4 signaling pathway; nervous system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; and postsynaptic membrane. Biomarker of amblyopia; congestive heart failure; interstitial cystitis; median neuropathy; and myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including lung cancer (multiple); mammary Paget's disease; reproductive organ cancer (multiple); stomach cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Erbb2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC619398 | View Product |
| Adenovirus | Transient expression | A619398 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG619398 | View Product |
| Gene knockout (non-viral) | PG619398 | View Product | |
| Gene knockout (AAV) | VG619398 | View Product | |
| CRISPR Activation | Gene activation | LA619398 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS619398 | View Product |
| Gene knockdown (AAV) | VS619398 | View Product | |
| ORF Vector | Template DNA | PC619398 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |