ESR1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ESR1-specific vectors and viral particles designed for reliable ESR1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ESR1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ESR1 Gene Overview
| Gene Name | estrogen receptor 1 |
|---|---|
| Gene Symbol | ESR1 |
| Synonyms | ER,ESR,Era,ESRA,ESTRR,NR3A1 |
| NCBI ID | 2099 |
| Ensembl ID | ENSG00000091831 |
| Uniprot ID | P03372 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020]
Human ESR1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC119498 | View Product |
| AAV Vector & Virus | Long-term expression | VC119498 | View Product |
| Adenovirus | Transient expression | A119498 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG119498 | View Product |
| Gene knockout (non-viral) | PG119498 | View Product | |
| Gene knockout (AAV) | VG119498 | View Product | |
| CRISPR Activation | Gene activation | LA119498 | View Product |
| siRNA Tools | Gene knockdown (AAV) | VS119498 | View Product |
| ORF Vector | Template DNA | PC119498 | View Product |
Mouse Esr1 Gene Overview
| Gene Name | estrogen receptor 1 (alpha) |
|---|---|
| Gene Symbol | Esr1 |
| Synonyms | ER,ERa,ESR,Estr,Estra,Nr3a1,ERalpha,ER-alpha |
| NCBI ID | 13982 |
| Ensembl ID | ENSMUSG00000019768 |
| Uniprot ID | P19785 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Mouse Esr1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC419498 | View Product |
| AAV Vector & Virus | Long-term expression | VC419498 | View Product |
| Adenovirus | Transient expression | A419498 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG430437 | View Product |
| Gene knockout (non-viral) | PG430437 | View Product | |
| Gene knockout (AAV) | VG430437 | View Product | |
| CRISPR Activation | Gene activation | LA430437 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS430437 | View Product |
| Gene knockdown (AAV) | VS430437 | View Product | |
| ORF Vector | Template DNA | PC419498 | View Product |
Rat Esr1 Gene Overview
| Gene Name | estrogen receptor 1 |
|---|---|
| Gene Symbol | Esr1 |
| Synonyms | Esr,ER-alpha,RNESTROR |
| NCBI ID | 24890 |
| Ensembl ID | ENSRNOG00000019358 |
| Uniprot ID | P06211 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including estrogen binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of signal transduction; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Esr1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC619498 | View Product |
| AAV Vector & Virus | Long-term expression | VC619498 | View Product |
| Adenovirus | Transient expression | A619498 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG619498 | View Product |
| Gene knockout (non-viral) | PG619498 | View Product | |
| Gene knockout (AAV) | VG619498 | View Product | |
| CRISPR Activation | Gene activation | LA619498 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS619498 | View Product |
| Gene knockdown (AAV) | VS619498 | View Product | |
| ORF Vector | Template DNA | PC619498 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |