FAP Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use FAP-specific vectors and viral particles designed for reliable FAP overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including FAP CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human FAP Gene Overview
| Gene Name | fibroblast activation protein alpha |
|---|---|
| Gene Symbol | FAP |
| Synonyms | FAPA,SIMP,DPPIV,FAPalpha |
| NCBI ID | 2191 |
| Ensembl ID | ENSG00000078098 |
| Uniprot ID | Q12884 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Human FAP Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC120240 | View Product |
| AAV Vector & Virus | Long-term expression | VC120240 | View Product |
| Adenovirus | Transient expression | A120240 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG120240 | View Product |
| Gene knockout (non-viral) | PG120240 | View Product | |
| Gene knockout (AAV) | VG120240 | View Product | |
| CRISPR Activation | Gene activation | LA120240 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS120240 | View Product |
| Gene knockdown (AAV) | VS120240 | View Product | |
| ORF Vector | Template DNA | PC120240 | View Product |
Mouse Fap Gene Overview
| Gene Name | fibroblast activation protein |
|---|---|
| Gene Symbol | Fap |
| Synonyms | SIMP |
| NCBI ID | 14089 |
| Ensembl ID | ENSMUSG00000000392 |
| Uniprot ID | P97321 |
| Gene Type | Protein coding |
Gene Summary
This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013]
Mouse Fap Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC420240 | View Product |
| AAV Vector & Virus | Long-term expression | VC420240 | View Product |
| Adenovirus | Transient expression | A420240 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG420240 | View Product |
| Gene knockout (non-viral) | PG420240 | View Product | |
| Gene knockout (AAV) | VG420240 | View Product | |
| CRISPR Activation | Gene activation | LA420240 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS420240 | View Product |
| Gene knockdown (AAV) | VS420240 | View Product | |
| ORF Vector | Template DNA | PC420240 | View Product |
Rat Fap Gene Overview
| Gene Name | fibroblast activation protein, alpha |
|---|---|
| Gene Symbol | Fap |
| Synonyms | |
| NCBI ID | 192203 |
| Ensembl ID | ENSRNOG00000005679 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including integrin binding activity; peptidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including melanocyte apoptotic process; melanocyte proliferation; and negative regulation of cell proliferation involved in contact inhibition. Predicted to be located in several cellular components, including basal part of cell; cell surface; and lamellipodium. Predicted to be part of peptidase complex. Predicted to be active in plasma membrane. Orthologous to human FAP (fibroblast activation protein alpha). [provided by Alliance of Genome Resources, Jul 2025]
Rat Fap Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC620240 | View Product |
| AAV Vector & Virus | Long-term expression | VC620240 | View Product |
| Adenovirus | Transient expression | A620240 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG620240 | View Product |
| Gene knockout (non-viral) | PG620240 | View Product | |
| Gene knockout (AAV) | VG620240 | View Product | |
| CRISPR Activation | Gene activation | LA620240 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS620240 | View Product |
| Gene knockdown (AAV) | VS620240 | View Product | |
| ORF Vector | Template DNA | PC620240 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |