FBXW7 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use FBXW7-specific vectors and viral particles designed for reliable FBXW7 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including FBXW7 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human FBXW7 Gene Overview
| Gene Name | F-box and WD repeat domain containing 7 |
|---|---|
| Gene Symbol | FBXW7 |
| Synonyms | AGO,CDC4,FBW6,FBW7,hAgo,FBX30,FBXW6,SEL10,hCdc4,DEDHIL,SEL-10 |
| NCBI ID | 55294 |
| Ensembl ID | ENSG00000109670 |
| Uniprot ID | Q969H0 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Human FBXW7 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC120370 | View Product |
| AAV Vector & Virus | Long-term expression | VC120370 | View Product |
| Adenovirus | Transient expression | A120370 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG120370 | View Product |
| Gene knockout (non-viral) | PG120370 | View Product | |
| Gene knockout (AAV) | VG120370 | View Product | |
| CRISPR Activation | Gene activation | LA120370 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS120370 | View Product |
| Gene knockdown (AAV) | VS120370 | View Product | |
| ORF Vector | Template DNA | PC120370 | View Product |
Mouse Fbxw7 Gene Overview
| Gene Name | F-box and WD-40 domain protein 7 |
|---|---|
| Gene Symbol | Fbxw7 |
| Synonyms | AGO,Cdc4,Fbw7,Fbwd6,Fbx30,Fbxw6,Fbxo30,SEL-10,1110001A17Rik |
| NCBI ID | 50754 |
| Ensembl ID | ENSMUSG00000028086 |
| Uniprot ID | Q8VBV4 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of osteoclast development; and positive regulation of proteolysis involved in protein catabolic process. Acts upstream of or within several processes, including Notch signaling pathway; protein destabilization; and vasculogenesis. Located in several cellular components, including Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in central nervous system; early conceptus; genitourinary system; and skeletal muscle tissue. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Fbxw7 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC420370 | View Product |
| Stable overexpression | LC520370 | View Product | |
| AAV Vector & Virus | Long-term expression | VC420370 | View Product |
| Long-term expression | VC520370 | View Product | |
| Adenovirus | Transient expression | A420370 | View Product |
| Transient expression | A520370 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG420370 | View Product |
| Gene knockout (non-viral) | PG420370 | View Product | |
| Gene knockout (AAV) | VG420370 | View Product | |
| CRISPR Activation | Gene activation | LA420370 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS420370 | View Product |
| Gene knockdown (AAV) | VS420370 | View Product | |
| ORF Vector | Template DNA | PC420370 | View Product |
| Template DNA | PC520370 | View Product |
Rat Fbxw7 Gene Overview
| Gene Name | F-box and WD repeat domain containing 7 |
|---|---|
| Gene Symbol | Fbxw7 |
| Synonyms | Fbw7 |
| NCBI ID | 100360914 |
| Ensembl ID | ENSRNOG00000010889 |
| Uniprot ID | D3Z902 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of intracellular signal transduction; and positive regulation of protein metabolic process. Predicted to act upstream of or within several processes, including Notch signaling pathway; protein destabilization; and vasculogenesis. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Apr 2025]
Rat Fbxw7 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |