FMR1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use FMR1-specific vectors and viral particles designed for reliable FMR1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including FMR1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human FMR1 Gene Overview
| Gene Name | fragile X messenger ribonucleoprotein 1 |
|---|---|
| Gene Symbol | FMR1 |
| Synonyms | POF,FMRP,POF1,FRAXA |
| NCBI ID | 2332 |
| Ensembl ID | ENSG00000102081 |
| Uniprot ID | Q06787 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010]
Human FMR1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC120704 | View Product |
| AAV Vector & Virus | Long-term expression | VC120704 | View Product |
| Adenovirus | Transient expression | A120704 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG120704 | View Product |
| Gene knockout (non-viral) | PG120704 | View Product | |
| Gene knockout (AAV) | VG120704 | View Product | |
| CRISPR Activation | Gene activation | LA120704 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS120704 | View Product |
| Gene knockdown (AAV) | VS120704 | View Product | |
| ORF Vector | Template DNA | PC120704 | View Product |
Mouse Fmr1 Gene Overview
| Gene Name | fragile X messenger ribonucleoprotein 1 |
|---|---|
| Gene Symbol | Fmr1 |
| Synonyms | FMRP,Fmr-1 |
| NCBI ID | 14265 |
| Ensembl ID | ENSMUSG00000000838 |
| Uniprot ID | P35922 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including N6-methyladenosine-containing RNA reader activity; RNA binding activity; and dynein complex binding activity. Involved in several processes, including chemical synaptic transmission; negative regulation of long-term synaptic depression; and post-transcriptional regulation of gene expression. Acts upstream of or within with a positive effect on miRNA-mediated post-transcriptional gene silencing. Acts upstream of or within central nervous system development and dendritic spine development. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; filopodium; and perikaryon. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and presynaptic cytosol. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and spleen. Used to study autism spectrum disorder; fragile X syndrome; and fragile X-associated tremor/ataxia syndrome. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (fragile X messenger ribonucleoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Fmr1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC420704 | View Product |
| AAV Vector & Virus | Long-term expression | VC420704 | View Product |
| Adenovirus | Transient expression | A420704 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG420704 | View Product |
| Gene knockout (non-viral) | PG420704 | View Product | |
| Gene knockout (AAV) | VG420704 | View Product | |
| CRISPR Activation | Gene activation | LA420704 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS420704 | View Product |
| Gene knockdown (AAV) | VS420704 | View Product | |
| ORF Vector | Template DNA | PC420704 | View Product |
Rat Fmr1 Gene Overview
| Gene Name | fragile X messenger ribonucleoprotein 1 |
|---|---|
| Gene Symbol | Fmr1 |
| Synonyms | FMRP |
| NCBI ID | 24948 |
| Ensembl ID | ENSRNOG00000057464 |
| Uniprot ID | Q80WE1 |
| Gene Type | Protein coding |
Gene Summary
Enables RNA binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including cell surface receptor signaling pathway; modulation of chemical synaptic transmission; and regulation of macromolecule metabolic process. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; dendrite; and distal axon. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic cytosol. Used to study autism spectrum disorder and fragile X syndrome. Biomarker of alcohol use disorder; myoclonic-atonic epilepsy; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (fragile X messenger ribonucleoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Fmr1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC620704 | View Product |
| AAV Vector & Virus | Long-term expression | VC620704 | View Product |
| Adenovirus | Transient expression | A620704 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG620704 | View Product |
| Gene knockout (non-viral) | PG620704 | View Product | |
| Gene knockout (AAV) | VG620704 | View Product | |
| CRISPR Activation | Gene activation | LA620704 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS620704 | View Product |
| Gene knockdown (AAV) | VS620704 | View Product | |
| ORF Vector | Template DNA | PC620704 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |