FOLH1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use FOLH1-specific vectors and viral particles designed for reliable FOLH1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including FOLH1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human FOLH1 Gene Overview
| Gene Name | folate hydrolase 1 |
|---|---|
| Gene Symbol | FOLH1 |
| Synonyms | PSM,FGCP,FOLH,GCP2,PSMA,mGCP,GCPII,NAALAD1 |
| NCBI ID | 2346 |
| Ensembl ID | ENSG00000086205 |
| Uniprot ID | Q04609 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Human FOLH1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC120736 | View Product |
| AAV Vector & Virus | Long-term expression | VC120736 | View Product |
| Adenovirus | Transient expression | A120736 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG120736 | View Product |
| Gene knockout (non-viral) | PG120736 | View Product | |
| Gene knockout (AAV) | VG120736 | View Product | |
| CRISPR Activation | Gene activation | LA120736 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS120736 | View Product |
| Gene knockdown (AAV) | VS120736 | View Product | |
| ORF Vector | Template DNA | PC120736 | View Product |
Mouse Folh1 Gene Overview
| Gene Name | folate hydrolase 1 |
|---|---|
| Gene Symbol | Folh1 |
| Synonyms | GCP2,mopsm |
| NCBI ID | 53320 |
| Ensembl ID | ENSMUSG00000001773 |
| Uniprot ID | O35409 |
| Gene Type | Protein coding |
Gene Summary
Enables carboxypeptidase activity and dipeptidase activity. Acts upstream of or within folic acid-containing compound metabolic process and proteolysis. Located in plasma membrane. Is expressed in central nervous system; male reproductive gland or organ; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and cerebral infarction. Orthologous to several human genes including FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Folh1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC420736 | View Product |
| Stable overexpression | LC520736 | View Product | |
| AAV Vector & Virus | Long-term expression | VC420736 | View Product |
| Long-term expression | VC520736 | View Product | |
| Adenovirus | Transient expression | A420736 | View Product |
| Transient expression | A520736 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG420736 | View Product |
| Gene knockout (non-viral) | PG420736 | View Product | |
| Gene knockout (AAV) | VG420736 | View Product | |
| CRISPR Activation | Gene activation | LA420736 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS420736 | View Product |
| Gene knockdown (AAV) | VS420736 | View Product | |
| ORF Vector | Template DNA | PC420736 | View Product |
| Template DNA | PC520736 | View Product |
Rat Folh1 Gene Overview
| Gene Name | folate hydrolase 1 |
|---|---|
| Gene Symbol | Folh1 |
| Synonyms | Naalad |
| NCBI ID | 85309 |
| Ensembl ID | ENSRNOG00000013770 |
| Uniprot ID | P70627 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable Ac-Asp-Glu binding activity; exopeptidase activity; and tetrahydrofolyl-poly(glutamate) polymer binding activity. Involved in positive regulation of apoptotic process and protein catabolic process. Predicted to be located in cell surface and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and cerebral infarction. Orthologous to several human genes including FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Folh1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC620736 | View Product |
| AAV Vector & Virus | Long-term expression | VC620736 | View Product |
| Adenovirus | Transient expression | A620736 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG620736 | View Product |
| Gene knockout (non-viral) | PG620736 | View Product | |
| Gene knockout (AAV) | VG620736 | View Product | |
| CRISPR Activation | Gene activation | LA620736 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS620736 | View Product |
| Gene knockdown (AAV) | VS620736 | View Product | |
| ORF Vector | Template DNA | PC620736 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |