FOXO3 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use FOXO3-specific vectors and viral particles designed for reliable FOXO3 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including FOXO3 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human FOXO3 Gene Overview
| Gene Name | forkhead box O3 |
|---|---|
| Gene Symbol | FOXO3 |
| Synonyms | FOXO2,AF6q21,FKHRL1,FOXO3A,FKHRL1P2 |
| NCBI ID | 2309 |
| Ensembl ID | ENSG00000118689 |
| Uniprot ID | O43524 |
| Gene Type | Protein coding |
Gene Summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Human FOXO3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC120790 | View Product |
| AAV Vector & Virus | Long-term expression | VC120790 | View Product |
| Adenovirus | Transient expression | A120790 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG120790 | View Product |
| Gene knockout (non-viral) | PG120790 | View Product | |
| Gene knockout (AAV) | VG120790 | View Product | |
| CRISPR Activation | Gene activation | LA120790 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS120790 | View Product |
| Gene knockdown (AAV) | VS120790 | View Product | |
| ORF Vector | Template DNA | PC117297 | View Product |
Mouse Foxo3 Gene Overview
| Gene Name | forkhead box O3 |
|---|---|
| Gene Symbol | Foxo3 |
| Synonyms | Fkhr2,FKHRL1,Foxo3a,1110048B16Rik,2010203A17Rik |
| NCBI ID | 56484 |
| Ensembl ID | ENSMUSG00000048756 |
| Uniprot ID | Q9WVH4 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial transcription; positive regulation of muscle atrophy; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including DNA damage response, signal transduction by p53 class mediator; extrinsic apoptotic signaling pathway in absence of ligand; and female gonad development. Located in cytosol; mitochondrial outer membrane; and nucleus. Part of protein-containing complex. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and hemolymphoid system. Used to study dermoid cyst of ovary. Orthologous to human FOXO3 (forkhead box O3). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Foxo3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC420790 | View Product |
| AAV Vector & Virus | Long-term expression | VC420790 | View Product |
| Adenovirus | Transient expression | A420790 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG420790 | View Product |
| Gene knockout (non-viral) | PG420790 | View Product | |
| Gene knockout (AAV) | VG420790 | View Product | |
| CRISPR Activation | Gene activation | LA420790 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS420790 | View Product |
| Gene knockdown (AAV) | VS420790 | View Product | |
| ORF Vector | Template DNA | PC420790 | View Product |
Rat Foxo3 Gene Overview
| Gene Name | forkhead box O3 |
|---|---|
| Gene Symbol | Foxo3 |
| Synonyms | Fkhrl1,Foxo3a |
| NCBI ID | 294515 |
| Ensembl ID | ENSRNOG00000000299 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables transcription coregulator binding activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of programmed cell death; and response to glucocorticoid. Located in cytoplasm and nucleus. Biomarker of obesity. Orthologous to human FOXO3 (forkhead box O3). [provided by Alliance of Genome Resources, Jul 2025]
Rat Foxo3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC620790 | View Product |
| AAV Vector & Virus | Long-term expression | VC620790 | View Product |
| Adenovirus | Transient expression | A620790 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG620790 | View Product |
| Gene knockout (non-viral) | PG620790 | View Product | |
| Gene knockout (AAV) | VG620790 | View Product | |
| CRISPR Activation | Gene activation | LA620790 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS620790 | View Product |
| Gene knockdown (AAV) | VS620790 | View Product | |
| ORF Vector | Template DNA | PC620790 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |