FTO Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use FTO-specific vectors and viral particles designed for reliable FTO overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including FTO CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human FTO Gene Overview
| Gene Name | FTO alpha-ketoglutarate dependent dioxygenase |
|---|---|
| Gene Symbol | FTO |
| Synonyms | GDFD,IFEX9,ALKBH9,BMIQ14 |
| NCBI ID | 79068 |
| Ensembl ID | ENSG00000140718 |
| Uniprot ID | Q9C0B1 |
| Gene Type | Protein coding |
Gene Summary
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
Human FTO Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC121050 | View Product |
| AAV Vector & Virus | Long-term expression | VC121050 | View Product |
| Adenovirus | Transient expression | A121050 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG121050 | View Product |
| Gene knockout (non-viral) | PG121050 | View Product | |
| Gene knockout (AAV) | VG121050 | View Product | |
| CRISPR Activation | Gene activation | LA121050 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS121050 | View Product |
| Gene knockdown (AAV) | VS121050 | View Product | |
| ORF Vector | Template DNA | PC121050 | View Product |
Mouse Fto Gene Overview
| Gene Name | FTO alpha-ketoglutarate dependent dioxygenase |
|---|---|
| Gene Symbol | Fto |
| Synonyms | mKIAA1752 |
| NCBI ID | 26383 |
| Ensembl ID | ENSMUSG00000055932 |
| Uniprot ID | Q8BGW1 |
| Gene Type | Protein coding |
Gene Summary
Enables broad specificity oxidative DNA demethylase activity and oxidative RNA demethylase activity. Involved in several processes, including DNA alkylation repair; RNA repair; and regulation of respiratory system process. Located in nucleus. Is expressed in several structures, including alimentary system; cerebral cortex; gonad; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Fto Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC421050 | View Product |
| AAV Vector & Virus | Long-term expression | VC421050 | View Product |
| Adenovirus | Transient expression | A421050 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG421050 | View Product |
| Gene knockout (non-viral) | PG421050 | View Product | |
| Gene knockout (AAV) | VG421050 | View Product | |
| CRISPR Activation | Gene activation | LA421050 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS421050 | View Product |
| Gene knockdown (AAV) | VS421050 | View Product | |
| ORF Vector | Template DNA | PC421050 | View Product |
Rat Fto Gene Overview
| Gene Name | FTO, alpha-ketoglutarate dependent dioxygenase |
|---|---|
| Gene Symbol | Fto |
| Synonyms | RGD1305121 |
| NCBI ID | 291905 |
| Ensembl ID | ENSRNOG00000011728 |
| Uniprot ID | Q2A121 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Involved in several processes, including negative regulation of eating behavior; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to bisphenol A. Predicted to be located in cytosol and nuclear speck. Used to study sciatic neuropathy. Biomarker of metabolic dysfunction-associated steatotic liver disease; obesity; transient cerebral ischemia; traumatic brain injury; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2025]
Rat Fto Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC621050 | View Product |
| AAV Vector & Virus | Long-term expression | VC621050 | View Product |
| Adenovirus | Transient expression | A621050 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG621050 | View Product |
| Gene knockout (non-viral) | PG621050 | View Product | |
| Gene knockout (AAV) | VG621050 | View Product | |
| CRISPR Activation | Gene activation | LA621050 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS621050 | View Product |
| Gene knockdown (AAV) | VS621050 | View Product | |
| ORF Vector | Template DNA | PC621050 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |