GDF15 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use GDF15-specific vectors and viral particles designed for reliable GDF15 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including GDF15 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human GDF15 Gene Overview
| Gene Name | growth differentiation factor 15 |
|---|---|
| Gene Symbol | GDF15 |
| Synonyms | HG,PDF,MIC1,PLAB,MIC-1,NAG-1,PTGFB,GDF-15 |
| NCBI ID | 9518 |
| Ensembl ID | ENSG00000130513 |
| Uniprot ID | Q99988 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
Human GDF15 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC121416 | View Product |
| AAV Vector & Virus | Long-term expression | VC121416 | View Product |
| Adenovirus | Transient expression | A121416 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG121416 | View Product |
| Gene knockout (non-viral) | PG121416 | View Product | |
| Gene knockout (AAV) | VG121416 | View Product | |
| CRISPR Activation | Gene activation | LA121416 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS121416 | View Product |
| Gene knockdown (AAV) | VS121416 | View Product | |
| ORF Vector | Template DNA | PC121416 | View Product |
Mouse Gdf15 Gene Overview
| Gene Name | growth differentiation factor 15 |
|---|---|
| Gene Symbol | Gdf15 |
| Synonyms | SBF,MIC-1,NAG-1 |
| NCBI ID | 23886 |
| Ensembl ID | ENSMUSG00000038508 |
| Uniprot ID | Q9Z0J7 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation. [provided by RefSeq, Aug 2016]
Mouse Gdf15 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC421416 | View Product |
| AAV Vector & Virus | Long-term expression | VC421416 | View Product |
| Adenovirus | Transient expression | A421416 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG421416 | View Product |
| Gene knockout (non-viral) | PG421416 | View Product | |
| Gene knockout (AAV) | VG421416 | View Product | |
| CRISPR Activation | Gene activation | LA421416 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS421416 | View Product |
| Gene knockdown (AAV) | VS421416 | View Product | |
| ORF Vector | Template DNA | PC421416 | View Product |
Rat Gdf15 Gene Overview
| Gene Name | growth differentiation factor 15 |
|---|---|
| Gene Symbol | Gdf15 |
| Synonyms | |
| NCBI ID | 29455 |
| Ensembl ID | ENSRNOG00000019661 |
| Uniprot ID | Q9Z0J6 |
| Gene Type | Protein coding |
Gene Summary
Enables protein homodimerization activity. Predicted to be involved in several processes, including GDF15-GFRAL signaling pathway; reduction of food intake in response to dietary excess; and regulation of signal transduction. Predicted to act upstream of or within positive regulation of myoblast fusion. Located in extracellular region. Orthologous to human GDF15 (growth differentiation factor 15). [provided by Alliance of Genome Resources, Apr 2025]
Rat Gdf15 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC621416 | View Product |
| AAV Vector & Virus | Long-term expression | VC621416 | View Product |
| Adenovirus | Transient expression | A621416 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG621416 | View Product |
| Gene knockout (non-viral) | PG621416 | View Product | |
| Gene knockout (AAV) | VG621416 | View Product | |
| CRISPR Activation | Gene activation | LA621416 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS621416 | View Product |
| Gene knockdown (AAV) | VS621416 | View Product | |
| ORF Vector | Template DNA | PC621416 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |