GPBAR1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use GPBAR1-specific vectors and viral particles designed for reliable GPBAR1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including GPBAR1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human GPBAR1 Gene Overview
| Gene Name | G protein-coupled bile acid receptor 1 |
|---|---|
| Gene Symbol | GPBAR1 |
| Synonyms | BG37,TGR5,M-BAR,GPCR19,GPR131 |
| NCBI ID | 151306 |
| Ensembl ID | ENSG00000179921 |
| Uniprot ID | Q8TDU6 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Human GPBAR1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC122443 | View Product |
| AAV Vector & Virus | Long-term expression | VC122443 | View Product |
| Adenovirus | Transient expression | A122443 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG122443 | View Product |
| Gene knockout (non-viral) | PG122443 | View Product | |
| Gene knockout (AAV) | VG122443 | View Product | |
| CRISPR Activation | Gene activation | LA122443 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS122443 | View Product |
| Gene knockdown (AAV) | VS122443 | View Product | |
| ORF Vector | Template DNA | PC122443 | View Product |
Mouse Gpbar1 Gene Overview
| Gene Name | G protein-coupled bile acid receptor 1 |
|---|---|
| Gene Symbol | Gpbar1 |
| Synonyms | BG37,GPCR,TGR5,M-BAR,GPR131 |
| NCBI ID | 227289 |
| Ensembl ID | ENSMUSG00000064272 |
| Uniprot ID | Q80SS6 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable G protein-coupled bile acid receptor activity. Involved in regulation of bicellular tight junction assembly. Predicted to be located in cytoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in gut and male reproductive gland or organ. Orthologous to human GPBAR1 (G protein-coupled bile acid receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Gpbar1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC422443 | View Product |
| AAV Vector & Virus | Long-term expression | VC422443 | View Product |
| Adenovirus | Transient expression | A422443 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG422443 | View Product |
| Gene knockout (non-viral) | PG422443 | View Product | |
| Gene knockout (AAV) | VG422443 | View Product | |
| CRISPR Activation | Gene activation | LA422443 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS422443 | View Product |
| Gene knockdown (AAV) | VS422443 | View Product | |
| ORF Vector | Template DNA | PC422443 | View Product |
Rat Gpbar1 Gene Overview
| Gene Name | G protein-coupled bile acid receptor 1 |
|---|---|
| Gene Symbol | Gpbar1 |
| Synonyms | Tgr5,M-BAR |
| NCBI ID | 338443 |
| Ensembl ID | ENSRNOG00000087111 |
| Uniprot ID | Q80T02 |
| Gene Type | Protein coding |
Gene Summary
Enables G protein-coupled receptor activity. Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of cholangiocyte proliferation. Predicted to be located in cytoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of metabolic dysfunction-associated steatohepatitis and polycystic kidney disease. Orthologous to human GPBAR1 (G protein-coupled bile acid receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Gpbar1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC622443 | View Product |
| AAV Vector & Virus | Long-term expression | VC622443 | View Product |
| Adenovirus | Transient expression | A622443 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG622443 | View Product |
| Gene knockout (non-viral) | PG622443 | View Product | |
| Gene knockout (AAV) | VG622443 | View Product | |
| CRISPR Activation | Gene activation | LA622443 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS622443 | View Product |
| Gene knockdown (AAV) | VS622443 | View Product | |
| ORF Vector | Template DNA | PC622443 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |