GPC3 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use GPC3-specific vectors and viral particles designed for reliable GPC3 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including GPC3 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human GPC3 Gene Overview
| Gene Name | glypican 3 |
|---|---|
| Gene Symbol | GPC3 |
| Synonyms | SGB,DGSX,MXR7,SDYS,SGBS,OCI-5,SGBS1,GTR2-2 |
| NCBI ID | 2719 |
| Ensembl ID | ENSG00000147257 |
| Uniprot ID | P51654 |
| Gene Type | Protein coding |
Gene Summary
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Human GPC3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC122448 | View Product |
| AAV Vector & Virus | Long-term expression | VC122448 | View Product |
| Adenovirus | Transient expression | A122448 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG122448 | View Product |
| Gene knockout (non-viral) | PG122448 | View Product | |
| Gene knockout (AAV) | VG122448 | View Product | |
| CRISPR Activation | Gene activation | LA122448 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS122448 | View Product |
| Gene knockdown (AAV) | VS122448 | View Product | |
| ORF Vector | Template DNA | PC122448 | View Product |
Mouse Gpc3 Gene Overview
| Gene Name | glypican 3 |
|---|---|
| Gene Symbol | Gpc3 |
| Synonyms | OCI-5 |
| NCBI ID | 14734 |
| Ensembl ID | ENSMUSG00000055653 |
| Uniprot ID | Q8CFZ4 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable peptidyl-dipeptidase inhibitor activity. Involved in mesenchymal cell proliferation involved in ureteric bud development. Acts upstream of or within several processes, including kidney development; positive regulation of transport; and regulation of signal transduction. Located in lysosome and plasma membrane. Is expressed in several structures, including brain; branchial arch; embryo mesenchyme; lower jaw; and urinary system. Used to study Simpson-Golabi-Behmel syndrome type 1. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Orthologous to human GPC3 (glypican 3). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Gpc3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC422448 | View Product |
| AAV Vector & Virus | Long-term expression | VC422448 | View Product |
| Adenovirus | Transient expression | A422448 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG422448 | View Product |
| Gene knockout (non-viral) | PG422448 | View Product | |
| Gene knockout (AAV) | VG422448 | View Product | |
| CRISPR Activation | Gene activation | LA422448 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS422448 | View Product |
| Gene knockdown (AAV) | VS422448 | View Product | |
| ORF Vector | Template DNA | PC422448 | View Product |
Rat Gpc3 Gene Overview
| Gene Name | glypican 3 |
|---|---|
| Gene Symbol | Gpc3 |
| Synonyms | OCI-5 |
| NCBI ID | 25236 |
| Ensembl ID | ENSRNOG00000060179 |
| Uniprot ID | P13265 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable peptidyl-dipeptidase inhibitor activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1 and nephroblastoma. Orthologous to human GPC3 (glypican 3). [provided by Alliance of Genome Resources, Jul 2025]
Rat Gpc3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC622448 | View Product |
| AAV Vector & Virus | Long-term expression | VC622448 | View Product |
| siRNA Tools | Gene knockdown (AAV) | VS622448 | View Product |
| ORF Vector | Template DNA | PC622448 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |