GSK3B Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use GSK3B-specific vectors and viral particles designed for reliable GSK3B overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including GSK3B CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human GSK3B Gene Overview
| Gene Name | glycogen synthase kinase 3 beta |
|---|---|
| Gene Symbol | GSK3B |
| Synonyms | |
| NCBI ID | 2932 |
| Ensembl ID | ENSG00000082701 |
| Uniprot ID | P49841 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
Human GSK3B Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| AAV Vector & Virus | Long-term expression | VC122736 | View Product |
| Adenovirus | Transient expression | A122736 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG122736 | View Product |
| Gene knockout (non-viral) | PG122736 | View Product | |
| Gene knockout (AAV) | VG122736 | View Product | |
| CRISPR Activation | Gene activation | LA122736 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS122736 | View Product |
| Gene knockdown (AAV) | VS122736 | View Product | |
| ORF Vector | Template DNA | PC122736 | View Product |
Mouse Gsk3b Gene Overview
| Gene Name | glycogen synthase kinase 3 beta |
|---|---|
| Gene Symbol | Gsk3b |
| Synonyms | GSK3,GSK-3,GSK-3beta,7330414F15Rik,8430431H08Rik |
| NCBI ID | 56637 |
| Ensembl ID | ENSMUSG00000022812 |
| Uniprot ID | Q9WV60 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and tau-protein kinase activity. Involved in several processes, including apoptotic signaling pathway; positive regulation of organelle organization; and regulation of macromolecule biosynthetic process. Acts upstream of with a positive effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of protein metabolic process; and regulation of neuron projection development. Located in several cellular components, including dendritic shaft; growth cone; and neuronal cell body. Part of Wnt signalosome; beta-catenin destruction complex; and ribonucleoprotein complex. Is active in glutamatergic synapse; meiotic spindle; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Gsk3b Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC422736 | View Product |
| AAV Vector & Virus | Long-term expression | VC422736 | View Product |
| Adenovirus | Transient expression | A422736 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG422736 | View Product |
| Gene knockout (non-viral) | PG422736 | View Product | |
| Gene knockout (AAV) | VG422736 | View Product | |
| CRISPR Activation | Gene activation | LA422736 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS422736 | View Product |
| Gene knockdown (AAV) | VS422736 | View Product | |
| ORF Vector | Template DNA | PC422736 | View Product |
Rat Gsk3b Gene Overview
| Gene Name | glycogen synthase kinase 3 beta |
|---|---|
| Gene Symbol | Gsk3b |
| Synonyms | |
| NCBI ID | 84027 |
| Ensembl ID | ENSRNOG00000002833 |
| Uniprot ID | P18266 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including ATP binding activity; protein serine/threonine kinase binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of neuron projection development; and regulation of synapse organization. Located in several cellular components, including axon; dendritic spine; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); depressive disorder; diabetic encephalopathy; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Jul 2025]
Rat Gsk3b Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC622736 | View Product |
| AAV Vector & Virus | Long-term expression | VC622736 | View Product |
| Adenovirus | Transient expression | A622736 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG622736 | View Product |
| Gene knockout (non-viral) | PG622736 | View Product | |
| Gene knockout (AAV) | VG622736 | View Product | |
| CRISPR Activation | Gene activation | LA622736 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS622736 | View Product |
| Gene knockdown (AAV) | VS622736 | View Product | |
| ORF Vector | Template DNA | PC622736 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |