HAVCR2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use HAVCR2-specific vectors and viral particles designed for reliable HAVCR2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including HAVCR2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human HAVCR2 Gene Overview
| Gene Name | hepatitis A virus cellular receptor 2 |
|---|---|
| Gene Symbol | HAVCR2 |
| Synonyms | TIM3,CD366,KIM-3,SPTCL,TIMD3,Tim-3,TIMD-3,HAVcr-2 |
| NCBI ID | 84868 |
| Ensembl ID | ENSG00000135077 |
| Uniprot ID | Q8TDQ0 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
Human HAVCR2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A223034 | View Product |
| ORF Vector | Template DNA | PC223034 | View Product |
Mouse Havcr2 Gene Overview
| Gene Name | hepatitis A virus cellular receptor 2 |
|---|---|
| Gene Symbol | Havcr2 |
| Synonyms | Tim3,TIM-3,Timd3 |
| NCBI ID | 171285 |
| Ensembl ID | ENSMUSG00000020399 |
| Uniprot ID | Q8VIM0 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable metal ion binding activity and transmembrane signaling receptor activity. Involved in several processes, including regulation of cytokine production; regulation of defense response; and regulation of leukocyte activation. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including aorta-gonad-mesonephros; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Havcr2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC423034 | View Product |
| AAV Vector & Virus | Long-term expression | VC423034 | View Product |
| Adenovirus | Transient expression | A423034 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG423034 | View Product |
| Gene knockout (non-viral) | PG423034 | View Product | |
| Gene knockout (AAV) | VG423034 | View Product | |
| CRISPR Activation | Gene activation | LA423034 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS423034 | View Product |
| Gene knockdown (AAV) | VS423034 | View Product | |
| ORF Vector | Template DNA | PC423034 | View Product |
Rat Havcr2 Gene Overview
| Gene Name | hepatitis A virus cellular receptor 2 |
|---|---|
| Gene Symbol | Havcr2 |
| Synonyms | tim3 |
| NCBI ID | 363578 |
| Ensembl ID | ENSRNOG00000031443 |
| Uniprot ID | P0C0K5 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including regulation of cytokine production; regulation of defense response; and regulation of leukocyte activation. Located in cell surface. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Havcr2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC623034 | View Product |
| AAV Vector & Virus | Long-term expression | VC623034 | View Product |
| Adenovirus | Transient expression | A623034 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG623034 | View Product |
| Gene knockout (non-viral) | PG623034 | View Product | |
| Gene knockout (AAV) | VG623034 | View Product | |
| CRISPR Activation | Gene activation | LA623034 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS623034 | View Product |
| Gene knockdown (AAV) | VS623034 | View Product | |
| ORF Vector | Template DNA | PC623034 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |