HDAC4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use HDAC4-specific vectors and viral particles designed for reliable HDAC4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including HDAC4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human HDAC4 Gene Overview
| Gene Name | histone deacetylase 4 |
|---|---|
| Gene Symbol | HDAC4 |
| Synonyms | HD4,AHO3,BDMR,HDACA,HA6116,HDAC-4,HDAC-A,NEDCHF,NEDCHID |
| NCBI ID | 9759 |
| Ensembl ID | ENSG00000068024 |
| Uniprot ID | P56524 |
| Gene Type | Protein coding |
Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Human HDAC4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC123132 | View Product |
| AAV Vector & Virus | Long-term expression | VC123132 | View Product |
| Adenovirus | Transient expression | A123132 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG123132 | View Product |
| Gene knockout (non-viral) | PG123132 | View Product | |
| Gene knockout (AAV) | VG123132 | View Product | |
| CRISPR Activation | Gene activation | LA123132 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS123132 | View Product |
| Gene knockdown (AAV) | VS123132 | View Product | |
| ORF Vector | Template DNA | PC123132 | View Product |
Mouse Hdac4 Gene Overview
| Gene Name | histone deacetylase 4 |
|---|---|
| Gene Symbol | Hdac4 |
| Synonyms | HD4,4932408F19Rik |
| NCBI ID | 208727 |
| Ensembl ID | ENSMUSG00000026313 |
| Uniprot ID | Q6NZM9 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including chromatin binding activity; protein kinase binding activity; and transcription corepressor activity. Involved in regulation of nucleobase-containing compound metabolic process and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; osteoblast development; and regulation of myotube differentiation. Located in several cellular components, including actomyosin; cytosol; and neuromuscular junction. Is expressed in several structures, including alimentary system; early embryo; forelimb; ganglia; and telencephalon. Used to study eating disorder. Human ortholog(s) of this gene implicated in ataxia telangiectasia; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Hdac4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC423132 | View Product |
| AAV Vector & Virus | Long-term expression | VC423132 | View Product |
| Adenovirus | Transient expression | A423132 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG423132 | View Product |
| Gene knockout (non-viral) | PG423132 | View Product | |
| Gene knockout (AAV) | VG423132 | View Product | |
| CRISPR Activation | Gene activation | LA423132 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS423132 | View Product |
| Gene knockdown (AAV) | VS423132 | View Product | |
| ORF Vector | Template DNA | PC423132 | View Product |
Rat Hdac4 Gene Overview
| Gene Name | histone deacetylase 4 |
|---|---|
| Gene Symbol | Hdac4 |
| Synonyms | |
| NCBI ID | 363287 |
| Ensembl ID | ENSRNOG00000020372 |
| Uniprot ID | Q99P99 |
| Gene Type | Protein coding |
Gene Summary
Enables promoter-specific chromatin binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and positive regulation of lamellipodium assembly. Located in A band and Z disc. Part of protein-containing complex. Biomarker of fetal alcohol spectrum disorder and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in ataxia telangiectasia; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Jul 2025]
Rat Hdac4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |